Substrate-induced remodeling of the active site regulates human HTRA1 activity
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Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell EnvelopeNewly folded substrates inside the molecular cage of the HtrA chaperone DegQThe structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteasesCatalytic Mechanism and Mode of Action of the Periplasmic Alginate Epimerase AlgGProtoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine proteaseAlpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissueStructural and Functional Analysis of Human HtrA3 Protease and Its SubdomainsComparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) geneLysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.The autolysis of human HtrA1 is governed by the redox state of its N-terminal domainComposition and proteolytic processing of corneal deposits associated with mutations in the TGFBI geneChemical biology approaches reveal conserved features of a C-terminal processing PDZ protease.Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.Serine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid depositsDetrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration.Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants.The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferationTemperature-induced changes of HtrA2(Omi) protease activity and structureNew approaches for dissecting protease functions to improve probe development and drug discoveryArchitecture and regulation of HtrA-family proteins involved in protein quality control and stress response.Ebola virus envelope glycoprotein derived peptide in human Furin-bound state: computational studies.The salt-sensitive structure and zinc inhibition of Borrelia burgdorferi protease BbHtrA.Magnetite Biomineralization in Magnetospirillum magneticum Is Regulated by a Switch-like Behavior in the HtrA Protease MamE.Determinants of amyloid fibril degradation by the PDZ protease HTRA1.Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity.HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.Two novel heterozygous HTRA1 mutations in two pedigrees with cerebral small vessel disease families.Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors.Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2.Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes.The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis.HTRA1 hydrolyzes ACAN (Aggrecan)Ahp cyclodepsipeptides: the impact of the Ahp residue on the "canonical inhibition" of S1 serine proteases.The first Greek case of heterozygous cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy: An atypical clinico-radiological presentation.Amyloid assembly and disassembly
P2860
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P2860
Substrate-induced remodeling of the active site regulates human HTRA1 activity
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@ast
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@en
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@nl
type
label
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@ast
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@en
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@nl
prefLabel
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@ast
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@en
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@nl
P2093
P2860
P50
P3181
P356
P1476
Substrate-induced remodeling of the active site regulates human HTRA1 activity
@en
P2093
Flavia Canellas
Linda Truebestein
Markus Kaiser
Timon Mönig
P2860
P2888
P3181
P356
10.1038/NSMB.2013
P577
2011-03-01T00:00:00Z
P5875
P6179
1053742848