Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.
about
Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesisComplete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificityStructural characterization of CalO2: A putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathwayStructural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathwayStructure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19Recent advances and novel treatment paradigms in acute lymphocytic leukemiaEnzymatic methods for glyco(diversification/randomization) of drugs and small moleculesNatural-product sugar biosynthesis and enzymatic glycodiversification.Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: results of a phase I/II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab.A phase 2 study of inotuzumab ozogamicin and rituximab, followed by autologous stem cell transplant in patients with relapsed/refractory diffuse large B-cell lymphoma.Prognostic factors for outcome in patients with refractory and relapsed acute lymphocytic leukemia treated with inotuzumab ozogamicin, a CD22 monoclonal antibody.Feasibility of allografting in patients with advanced acute lymphoblastic leukemia after salvage therapy with inotuzumab ozogamicin.Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model.From nature to the laboratory and into the clinicThe biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response.Biosynthesis of enediyne antitumor antibioticsSynthesis of the carboline disaccharide domain of shishijimicin A.Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.Tumour-targeted chemotherapy with immunoconjugates of calicheamicin.Monoclonal antibody-based therapies: a new dawn in the treatment of acute lymphoblastic leukemiaA phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia.A sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detectionCharacterization of CalE10, the N-oxidase involved in calicheamicin hydroxyaminosugar formationSite-specific antibody drug conjugates for cancer therapyInotuzumab ozogamicin in the treatment of B-cell acute lymphoblastic leukemia.Drug conjugates such as Antibody Drug Conjugates (ADCs), immunotoxins and immunoliposomes challenge daily clinical practice.Antibody-based therapies in B-cell lineage acute lymphoblastic leukaemia.Philadelphia chromosome-negative acute lymphoblastic leukemia: therapies under development.Modern immunotherapy of adult B-lineage acute lymphoblastic leukemia with monoclonal antibodies and chimeric antigen receptor modified T cells.Inotuzumab ozogamicin in B-cell acute lymphoblastic leukemias and non-Hodgkin's lymphomas.Future of Therapy in Acute Lymphoblastic Leukemia (ALL)--Potential Role of Immune-Based Therapies.Novel approaches to pediatric leukemia treatment.Inotuzumab ozogamicin in relapsed B-cell acute lymphoblastic leukemia.Novel therapy for childhood acute lymphoblastic leukemia.Synthesis and anticancer activity of 13-membered cyclic enediynes.Calicheamicin γ1(I) and phenyl tert-butyl nitrone (PBN): observation of a kinetic isotope effect by an ESR study.
P2860
Q24621823-994FB81F-1AA4-474C-8D02-3F3060C1F3EAQ24633480-937C651A-2B29-455D-B72A-80E0E65E21EBQ27650879-88521295-7651-4995-A630-6C7F386AF07DQ27667100-89C94F5C-A098-43BE-8B86-F6EC6F6E33FFQ27684894-E7FBAB7B-F453-49AA-818E-022FD3162FEAQ28078076-564C824D-5765-4C8E-9DCF-BED585AC0ECEQ28247479-A9B7C1A5-24E3-4214-B5D8-6E260311392AQ30492476-86C7CBE2-7E87-4C7D-BC17-474DF161BD13Q33405150-0F51BAB2-3FEF-450E-BE89-E2F7398FAC8CQ33420631-A29C7D99-F6C4-4212-A037-3E61645CA910Q33893777-788861C7-513D-44F0-B576-BE46F21479A6Q33915990-1CE99AAC-480B-4253-9B7C-A33459304AB3Q34267723-9648E538-F10F-4857-8648-9001E1720FA4Q34657694-C60B48CB-BC18-444D-B9EE-CF4AB213CD83Q34760022-DCF1AF08-21EF-4551-A8C3-B36397D58492Q34819635-8B94FB21-1A7C-4813-9333-A30AEFD1E15AQ35024692-65FA7006-53E9-4003-AB22-882CAE0028E1Q35136566-EC155171-3F96-4F3A-A59C-5E7BA6902415Q35460767-EAA131FC-1308-41FE-BF44-B5D360269618Q35759276-3AD6735A-6D7A-4F9A-AFBC-E06F8EC175F5Q35873771-C359587D-0213-4750-A8B3-C5DA3F6ACD1AQ36339717-75829C1A-AD57-4E57-88D2-A5F99A922478Q36446319-987904E2-8AE7-4327-A4D7-1246373DDE96Q36853353-1C253FEF-D627-4F36-9290-7AD80BF14F36Q37039074-A7857945-BEAA-493B-BEB4-07DEDD9747CBQ37138509-D063E6B0-4F9C-45CC-9577-0016582A7961Q37247384-41C5021F-3D89-4EC3-91F9-97DBBE6E85D3Q37593705-84DE4E65-9BBA-4811-8344-3ED8DC3598D2Q38002447-B8422C6E-8029-4373-AFE6-6741BF1A0D3DQ38084826-6024F9CD-AEF0-4BBE-98C4-9AC8D6125151Q38224988-6BDB6A69-9286-48AB-B8B4-1D6BDE1E4AFBQ38282458-DB0BB89D-8064-4DDD-A876-5E953BCE94AFQ38312596-713D6E23-1677-4163-AD26-FB128659061EQ38379829-BF8A7B0A-50CA-4DEE-8DFD-D1FDE30FDC9BQ38434000-F8CC7892-9C8A-4D0C-9711-EF20D57AAD50Q38500371-FD353A01-AE65-4DCA-82B8-F634EA4CFDF3Q38984055-BCF0B9A6-CE14-4747-85E2-A5063CFD3072Q39368957-193176D2-2092-4B78-838C-DCDAC94BE636Q39480351-97A874F1-DFFB-4E2D-9C2F-362D81DCF83BQ43189184-E5C8DF15-C9AF-491F-8C7B-C8A4E559F2B9
P2860
Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Understanding and exploiting n ...... ure of calicheamicin research.
@ast
Understanding and exploiting n ...... ure of calicheamicin research.
@en
Understanding and exploiting n ...... ure of calicheamicin research.
@nl
type
label
Understanding and exploiting n ...... ure of calicheamicin research.
@ast
Understanding and exploiting n ...... ure of calicheamicin research.
@en
Understanding and exploiting n ...... ure of calicheamicin research.
@nl
prefLabel
Understanding and exploiting n ...... ure of calicheamicin research.
@ast
Understanding and exploiting n ...... ure of calicheamicin research.
@en
Understanding and exploiting n ...... ure of calicheamicin research.
@nl
P2093
P356
P1476
Understanding and exploiting n ...... ture of calicheamicin research
@en
P2093
P304
P356
10.2174/1381612003398564
P577
2000-12-01T00:00:00Z