Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.
about
Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.On the mechanism of CFTR inhibition by a thiazolidinone derivative.Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance.Modulation of CFTR gating by permeant ions.Modeling the conformational changes underlying channel opening in CFTRLocalizing a gate in CFTR.Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7).Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.Identification of a novel post-hydrolytic state in CFTR gating.Molecular modelling and molecular dynamics of CFTR.Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.Transmembrane helical interactions in the CFTR channel pore.Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.The CFTR ion channel: gating, regulation, and anion permeationLong-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channelsCysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeationPositioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulatorVx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle.Spatial positioning of CFTR's pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathwayConverting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsTwo salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.Nonequilibrium gating of CFTR on an equilibrium theme.Functional architecture of the CFTR chloride channel.Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.Cytoplasmic pathway followed by chloride ions to enter the CFTR channel pore.Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore.Electrostatic tuning of the pre- and post-hydrolytic open states in CFTRArchitecture and functional properties of the CFTR channel pore.Tuning of CFTR chloride channel function by location of positive charges within the pore.Relative movements of transmembrane regions at the outer mouth of the cystic fibrosis transmembrane conductance regulator channel pore during channel gatingRole of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel.Alternating access to the transmembrane domain of the ATP-binding cassette protein cystic fibrosis transmembrane conductance regulator (ABCC7).Cystic fibrosis transmembrane conductance regulator: temperature-dependent cysteine reactivity suggests different stable conformers of the conduction pathwayOn the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator.Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): CLOSED AND OPEN STATE CHANNEL MODELS.Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel.Relative contribution of different transmembrane segments to the CFTR chloride channel pore.
P2860
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P2860
Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Dual roles of the sixth transm ...... nnel in gating and permeation.
@ast
Dual roles of the sixth transm ...... nnel in gating and permeation.
@en
Dual roles of the sixth transm ...... nnel in gating and permeation.
@nl
type
label
Dual roles of the sixth transm ...... nnel in gating and permeation.
@ast
Dual roles of the sixth transm ...... nnel in gating and permeation.
@en
Dual roles of the sixth transm ...... nnel in gating and permeation.
@nl
prefLabel
Dual roles of the sixth transm ...... nnel in gating and permeation.
@ast
Dual roles of the sixth transm ...... nnel in gating and permeation.
@en
Dual roles of the sixth transm ...... nnel in gating and permeation.
@nl
P2093
P2860
P356
P1476
Dual roles of the sixth transm ...... nnel in gating and permeation.
@en
P2093
Tzyh-Chang Hwang
Yonghong Bai
P2860
P304
P356
10.1085/JGP.201010480
P577
2010-09-01T00:00:00Z