Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta. - Wikidata - wikimedia - TriplyDB

Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta.

Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta.

http://www.wikidata.org/entity/Q34097322

about

GSK-3β: A Bifunctional Role in Cell Death Pathways Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'Regulation of autophagy by cytoplasmic p53 Alterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 Mutants Mucosal injuries due to ribosome-inactivating stress and the compensatory responses of the intestinal epithelial barrier Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development Endoplasmic reticulum stress stimulates p53 expression through NF-κB activation Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis.The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-κB pathways.Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifs The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways.Differential modulatory effects of GSK-3β and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma.Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells Differential Proteomic Analysis of Human Placenta-Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan-Coated Surface.Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis.p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.Potential for therapeutic manipulation of the UPR in disease.Endoplasmic reticulum stress in disease pathogenesis GSK3 beta N-terminus binding to p53 promotes its acetylation.Endoplasmic reticulum stress and the pancreatic acinar cell.eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies.Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes.The unfolded protein response in lung disease.Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment.Proteomics and metabolomics in cancer drug development.Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications.Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1.ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells.Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death.Negative regulation of mTORC2 by glycogen synthase kinase-3β: an adaptive process to stress with an anticancer therapeutic potential?The pro-apoptotic substance thapsigargin selectively stimulates re-growth of brain capillaries.The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.The Impact of Paeoniflorin on α-Synuclein Degradation Pathway.Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest.Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein response Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer.

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P2860

Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta.

http://www.wikidata.org/entity/Q34097322

description

2005 nî lūn-bûn

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2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Endoplasmic reticulum stress a ...... lycogen synthase kinase 3beta.

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Endoplasmic reticulum stress a ...... lycogen synthase kinase 3beta.

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Endoplasmic reticulum stress a ...... lycogen synthase kinase 3beta.

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Endoplasmic reticulum stress a ...... lycogen synthase kinase 3beta.

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Endoplasmic reticulum stress a ...... lycogen synthase kinase 3beta.

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MCB.25.21.9392-9405.2005

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Molecular and Cellular Biology

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Endoplasmic reticulum stress a ...... lycogen synthase kinase 3beta.

@en

P2093

Antonis E Koromilas

http://www.w3.org/2001/XMLSchema#string

Dionissios Baltzis

http://www.w3.org/2001/XMLSchema#string

Li-Ke Qu

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Olivier Pluquet

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P2860

Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

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9392-9405

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10.1128/MCB.25.21.9392-9405.2005

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21

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25

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7538007

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16227590

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endoplasmic reticulum

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1265800

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