Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
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Activation of an alternative, rec12 (spo11)-independent pathway of fission yeast meiotic recombination in the absence of a DNA flap endonucleaseAcetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediatesStimulation of flap endonuclease-1 by the Bloom's syndrome proteinHuman DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediatesIsolation of human Dna2 endonuclease and characterization of its enzymatic propertiesComponents of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processingOkazaki fragment maturation: nucleases take centre stageEnzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNAAdvances in mechanisms of genetic instability related to hereditary neurological diseases.Association between FEN1 Polymorphisms -69G>A and 4150G>T with Susceptibility in Human Disease: A Meta-AnalysisNucleases in homologous recombination as targets for cancer therapyUnpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleasesPhosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulationFlap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason scoreOverexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancersProliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stageWuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer riskVariants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in ChinaDirect observation of DNA threading in flap endonuclease complexesHaploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouseOn the mechanism of gene amplification induced under stress in Escherichia coliMolecular interactions of Escherichia coli ExoIX and identification of its associated 3'-5' exonuclease activity.Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.Genetic mechanisms in Apc-mediated mammary tumorigenesisFlap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese populationHemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis.High mobility of flap endonuclease 1 and DNA polymerase eta associated with replication foci in mammalian S-phase nucleus.Human RECQL5beta stimulates flap endonuclease 1Reconstitution of eukaryotic lagging strand DNA replication.Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation.The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.Potassium bromate, a potent DNA oxidizing agent, exacerbates germline repeat expansion in a fragile X premutation mouse modelIncreased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer.Kinetics of endogenous mouse FEN1 in base excision repair.Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity.Functional regulation of FEN1 nuclease and its link to cancerEukaryotic lagging strand DNA replication employs a multi-pathway mechanism that protects genome integrityGenetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk.
P2860
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P2860
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
@ast
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
@en
Haploinsufficiency of Flap endonuclease
@nl
type
label
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
@ast
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
@en
Haploinsufficiency of Flap endonuclease
@nl
prefLabel
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
@ast
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
@en
Haploinsufficiency of Flap endonuclease
@nl
P2093
P2860
P356
P1476
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
@en
P2093
Anthony M C Brown
Burkhard Kneitz
Joerg Heyer
Kunhua Fan
Mari Kuraguchi
Martin Lipkin
Melanie Kucherlapati
P2860
P304
P356
10.1073/PNAS.152321699
P407
P577
2002-07-15T00:00:00Z