RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain.
about
RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory.The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunitsRGS14 at the interface of hippocampal signaling and synaptic plasticityRGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathwaysActivation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8ARegulator of G-protein signaling 14 (RGS14) is a selective H-Ras effectorRole of layer 6 of V2 visual cortex in object-recognition memoryThe RGS14 GoLoco domain discriminates among Galphai isoformsG protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cellsIntegration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14).Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors.The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins.Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain.Group II activators of G-protein signalling and proteins containing a G-protein regulatory motif.Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain.Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A.The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling.RGS14 regulates the lifetime of Gα-GTP signaling but does not prolong Gβγ signaling following receptor activation in live cells.Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleusBioluminescence resonance energy transfer to detect protein-protein interactions in live cells.The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function.RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling.Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and DiseaseRegulation of RGS2 and Second Messenger Signaling in Vascular Smooth Muscle Cells by cGMP-dependent Protein Kinase
P2860
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P2860
RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain.
description
2001 nî lūn-bûn
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2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2001年の論文
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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RGS14 is a bifunctional regula ...... multiple populations in brain.
@ast
RGS14 is a bifunctional regula ...... multiple populations in brain.
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RGS14 is a bifunctional regula ...... multiple populations in brain.
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label
RGS14 is a bifunctional regula ...... multiple populations in brain.
@ast
RGS14 is a bifunctional regula ...... multiple populations in brain.
@en
RGS14 is a bifunctional regula ...... multiple populations in brain.
@nl
prefLabel
RGS14 is a bifunctional regula ...... multiple populations in brain.
@ast
RGS14 is a bifunctional regula ...... multiple populations in brain.
@en
RGS14 is a bifunctional regula ...... multiple populations in brain.
@nl
P2093
P2860
P1476
RGS14 is a bifunctional regula ...... multiple populations in brain.
@en
P2093
Goldman EH
Hollinger S
P2860
P304
P356
10.1046/J.1471-4159.2001.00629.X
P407
P577
2001-12-01T00:00:00Z