Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
about
Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH).1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donorCrystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureusRole of fatty acids in Bacillus environmental adaptationBacterial lipids: metabolism and membrane homeostasisStructure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesisProbing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substratesStructural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestisIdentification of functional differences in metabolic networks using comparative genomics and constraint-based modelsDetermination of selectivity and efficacy of fatty acid synthesis inhibitors.Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.2,5-dialkylresorcinol biosynthesis in Pseudomonas aurantiaca: novel head-to-head condensation of two fatty acid-derived precursorsFabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureusFatty acid biosynthesis as a target for novel antibacterialsProduct diversity and regulation of type II fatty acid synthases.Inhibiting bacterial fatty acid synthesis.Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracisCloning, expression, crystallization and preliminary X-ray crystallographic analysis of beta-ketoacyl-ACP synthase III (FabH) from Xanthomonas oryzae pv. oryzaeBioactive pyridine-N-oxide disulfides from Allium stipitatum.Protein targets for structure-based anti-Mycobacterium tuberculosis drug discovery.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Novel FabH inhibitors: a patent and article literature review (2000--2012).Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.Structural evidence for the covalent modification of FabH by 4,5-dichloro-1,2-dithiol-3-one (HR45).Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity.
P2860
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P2860
Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
description
2002 nî lūn-bûn
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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Purification, characterization ...... bH) from Staphylococcus aureus
@ast
Purification, characterization ...... bH) from Staphylococcus aureus
@en
Purification, characterization ...... bH) from Staphylococcus aureus
@nl
type
label
Purification, characterization ...... bH) from Staphylococcus aureus
@ast
Purification, characterization ...... bH) from Staphylococcus aureus
@en
Purification, characterization ...... bH) from Staphylococcus aureus
@nl
prefLabel
Purification, characterization ...... bH) from Staphylococcus aureus
@ast
Purification, characterization ...... bH) from Staphylococcus aureus
@en
Purification, characterization ...... bH) from Staphylococcus aureus
@nl
P2860
P1476
Purification, characterization ...... bH) from Staphylococcus aureus
@en
P2093
Kevin A Reynolds
P2860
P304
P356
10.1128/AAC.46.5.1310-1318.2002
P407
P577
2002-05-01T00:00:00Z