Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development.
about
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseasesCrystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatasesSubstrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrateLarge-scale structural analysis of the classical human protein tyrosine phosphatomeAssociation of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healingKinetic and structural analysis of a bacterial protein tyrosine phosphatase-like myo-inositol polyphosphataseRole of Striatal-Enriched Tyrosine Phosphatase in Neuronal FunctionSmall molecule tools for functional interrogation of protein tyrosine phosphatasesA novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation.Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitorCrystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitorStructural insights into molecular function of the metastasis-associated phosphatase PRL-3Overproduction, purification and structure determination of human dual-specificity phosphatase 14Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factorSalicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Insights into the Reaction of Protein-tyrosine Phosphatase 1B: CRYSTAL STRUCTURES FOR TRANSITION STATE ANALOGS OF BOTH CATALYTIC STEPSThe Trypanosoma brucei Life Cycle Switch TbPTP1 Is Structurally Conserved and Dephosphorylates the Nucleolar Protein NOPP44/46Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogueCrystal structure of human protein tyrosine phosphatase SHP-1 in the open conformationStructure of human dual-specificity phosphatase 27 at 2.38 Å resolutionIsothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of theYersinia pestisprotein tyrosine phosphatase YopHStructural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesisA Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 DiabetesStructure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas’ diseaseConformational Basis for Substrate Recruitment in Protein Tyrosine Phosphatase 10DAtomic Structure of Dual-Specificity Phosphatase 26, a Novel p53 PhosphataseA Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune DiseasesDiverse Levels of Sequence Selectivity and Catalytic Efficiency of Protein-Tyrosine PhosphatasesThe molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1BHigh-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substratesGold compounds as therapeutic agents for human diseasesProtein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase functionIdentification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approachTransduction of redox signaling by electrophile-protein reactionsDiscovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases.Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague.Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library.Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding.
P2860
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P2860
Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@ast
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@en
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@nl
type
label
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@ast
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@en
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@nl
prefLabel
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@ast
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@en
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@nl
P1476
Protein tyrosine phosphatases: ...... ty, and inhibitor development.
@en
P2093
Zhong-Yin Zhang
P304
P356
10.1146/ANNUREV.PHARMTOX.42.083001.144616
P577
2002-01-01T00:00:00Z