Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kina

Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kina

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http://www.wikidata.org/entity/Q34113009

Q34113009

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New promises for metformin: advances in the understanding of its mechanisms of action The effect of environmental chemicals on the tumor microenvironment Entitymetrics: measuring the impact of entities Metformin protects skeletal muscle from cardiotoxin induced degeneration Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration.Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo.AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts.Effects of metformin on CD133+ colorectal cancer cells in diabetic patients Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells.Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer Recent prediagnostic aspirin use, lymph node involvement, and 5-year mortality in women with stage I-III breast cancer: a nationwide population-based cohort study Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells Metformin: an emerging new therapeutic option for targeting cancer stem cells and metastasis Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages.Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin.Durable response of glioblastoma to adjuvant therapy consisting of temozolomide and a weekly dose of AMD3100 (plerixafor), a CXCR4 inhibitor, together with lapatinib, metformin and niacinamide Hyperglycaemia-induced resistance to Docetaxel is negated by metformin: a role for IGFBP-2.Metformin targets multiple signaling pathways in cancer.Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling.Metformin as an antitumor agent in cancer prevention and treatment.Proteomic modulation in breast tumors after metformin exposure: results from a "window of opportunity" trial.Inhibition of Epithelial-Mesenchymal Transition and Metastasis by Combined TGFbeta Knockdown and Metformin Treatment in a Canine Mammary Cancer Xenograft Model.Screening of multi-targeted natural compounds for receptor tyrosine kinases inhibitors and biological evaluation on cancer cell lines, in silico and in vitro.Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression.Metformin induces cytotoxicity by down-regulating thymidine phosphorylase and excision repair cross-complementation 1 expression in non-small cell lung cancer cells.Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line.Insulin Resistance: Any Role in the Changing Epidemiology of Thyroid Cancer?Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production.Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation.Survival benefits in colorectal adenocarcinoma with the use of metformin among a black diabetic inner city population.Thrombin mediates migration of rat brain astrocytes via PLC, Ca²⁺, CaMKII, PKCα, and AP-1-dependent matrix metalloproteinase-9 expression.Effect of Metformin on Adult Hippocampal Neurogenesis: Comparison with Donepezil and Links to Cognition.Increased efficacy of metformin corresponds to differential metabolic effects in the ovarian tumors from obese versus lean mice.Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control.

P2860

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P2860

Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kina

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http://www.wikidata.org/entity/Q34113009

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2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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