Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis
about
Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant miceTransport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporterHuman CYP7A1 deficiency: progress and enigmasBile acid transporters in health and diseaseThe amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholateKey discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decadesX-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11CThe farnesoid X-receptor is an essential regulator of cholesterol homeostasisThe role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type IIATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes.Clinical application of transcriptional activators of bile salt transporters.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Bile formation and secretion.Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile acid stress.Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity.Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice.Transgenic overexpression of Abcb11 enhances biliary bile salt outputs, but does not affect cholesterol cholelithogenesis in miceHepatobiliary disposition of 3alpha,6alpha,7alpha,12alpha-tetrahydroxy-cholanoyl taurine: a substrate for multiple canalicular transporters.The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver diseaseRole of ABC transporters in secretion of cholesterol from liver into bile.Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.The ileal lipid binding protein is required for efficient absorption and transport of bile acids in the distal portion of the murine small intestine.Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet.Differences in presentation and progression between severe FIC1 and BSEP deficiencies.Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.Cholestatic liver disease: pathophysiology and therapeutic options.Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liverIntestinal transport and metabolism of bile acidsGenetics of familial intrahepatic cholestasis syndromes.Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in miceCholangiocyte anion exchange and biliary bicarbonate excretionHepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation.FXR and PXR: potential therapeutic targets in cholestasis.Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in LiverRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Biliary lipids and cholesterol gallstone disease.Regulation of hepatic bile acid transporters Ntcp and Bsep expression.Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP).Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.
P2860
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P2860
Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Targeted inactivation of siste ...... stent intrahepatic cholestasis
@ast
Targeted inactivation of siste ...... stent intrahepatic cholestasis
@en
Targeted inactivation of sister of P-glycoprotein gene
@nl
type
label
Targeted inactivation of siste ...... stent intrahepatic cholestasis
@ast
Targeted inactivation of siste ...... stent intrahepatic cholestasis
@en
Targeted inactivation of sister of P-glycoprotein gene
@nl
prefLabel
Targeted inactivation of siste ...... stent intrahepatic cholestasis
@ast
Targeted inactivation of siste ...... stent intrahepatic cholestasis
@en
Targeted inactivation of sister of P-glycoprotein gene
@nl
P2093
P2860
P356
P1476
Targeted inactivation of siste ...... stent intrahepatic cholestasis
@en
P2093
B Tuchweber
C Ackerley
C D Helgason
I M Yousef
M J Phillips
P2860
P304
P356
10.1073/PNAS.031465498
P407
P577
2001-02-06T00:00:00Z