The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA
about
Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phaseCRL4Cdt2: master coordinator of cell cycle progression and genome stabilityThymine DNA glycosylase is a CRL4Cdt2 substrate.Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomesCheckpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligaseDirect role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis.Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication.Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylationUb-family modifications at the replication fork: Regulating PCNA-interacting components.A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.
P2860
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P2860
The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@ast
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@en
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@nl
type
label
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@ast
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@en
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@nl
prefLabel
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@ast
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@en
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@nl
P2093
P2860
P356
P1476
The CRL4Cdt2 ubiquitin ligase ...... a direct association with PCNA
@en
P2093
Carlos R Herrera
Dong Hyun Kim
Hyung Wook Nam
P Renee Yew
Varija N Budhavarapu
Yu Sam Kim
P2860
P304
P356
10.1128/MCB.01135-09
P407
P577
2010-07-06T00:00:00Z