Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis
about
Whole-genome sequencing targets drug-resistant bacterial infectionsExpanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pecDesigning and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban SoilsEndless Resistance. Endless Antibiotics?Mining the metabiome: identifying novel natural products from microbial communities.Metagenomic small molecule discovery methods.Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonistDung-inhabiting fungi: a potential reservoir of novel secondary metabolites for the control of plant pathogens.Inhibition of the growth of Bacillus subtilis DSM10 by a newly discovered antibacterial protein from the soil metagenome.Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials.Emerging trends in the discovery of natural product antibacterials.Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.Strategies for target identification of antimicrobial natural products.Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants.Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products.Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation.Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance.Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters.Advancing Weed Management Strategies Using Metagenomic TechniquesMutation in Elongation Factor G Confers Resistance to the Antibiotic Argyrin in the Opportunistic PathogenPseudomonas aeruginosaStructures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of theMetagenomics: An Application Based Perspective
P2860
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P2860
Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@ast
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@en
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@nl
type
label
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@ast
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@en
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@nl
prefLabel
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@ast
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@en
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@nl
P2093
P2860
P356
P1476
Environmental DNA-encoded anti ...... ype II fatty acid biosynthesis
@en
P2093
Boojala Vijay B Reddy
Debjani Chakraborty
Scott B Dewell
Sean F Brady
Zhiyang Feng
P2860
P304
P356
10.1021/JA207662W
P407
P577
2012-02-02T00:00:00Z