Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.
about
Escape Velocity: Why the Prospect of Extreme Human Life Extension Matters NowLimitations of allotopic expression of mitochondrial genes in mammalian cellsAllotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?The function of genomes in bioenergetic organellesMitochondrial DNA mutations in human diseaseWhy genes persist in organelle genomesLeber hereditary optic neuropathy: current perspectivesExtreme mitochondrial evolution in the ctenophore Mnemiopsis leidyi: Insight from mtDNA and the nuclear genomePopulation bottlenecks as a potential major shaping force of human genome architectureGene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated mitochondrial fission.Novel role of ATPase subunit C targeting peptides beyond mitochondrial protein import.Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects.Modeling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mitochondrial DNAA single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression.Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.Mitochondrial ATP synthase: architecture, function and pathology.An algal nucleus-encoded subunit of mitochondrial ATP synthase rescues a defect in the analogous human mitochondrial-encoded subunit.The optic nerve: a "mito-window" on mitochondrial neurodegenerationThe neuro-ophthalmology of mitochondrial diseaseGene therapy for the treatment of mitochondrial DNA disorders.Trial end points and natural history in patients with G11778A Leber hereditary optic neuropathy : preparation for gene therapy clinical trial.LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile.Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutantSafety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.mRNA localization to the mitochondrial surface allows the efficient translocation inside the organelle of a nuclear recoded ATP6 protein.Mitochondrial DNA: impacting central and peripheral nervous systems.Peptide-based carbon nanotubes for mitochondrial targeting.Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual systemLeber hereditary optic neuropathy gene therapy clinical trial recruitment: year 1.Mitochondrial energetics and therapeutics.Animal models of human mitochondrial DNA mutations.Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.Correcting human mitochondrial mutations with targeted RNA import.New insights into the bioenergetics of mitochondrial disorders using intracellular ATP reportersNuclear expression of a mitochondrial DNA gene: mitochondrial targeting of allotopically expressed mutant ATP6 in transgenic mice.Mitochondrial gene therapy improves respiration, biogenesis, and transcription in G11778A Leber's hereditary optic neuropathy and T8993G Leigh's syndrome cells.Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus.Delivery of drugs and macromolecules to mitochondria.
P2860
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P2860
Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@ast
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@en
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@nl
type
label
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@ast
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@en
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@nl
prefLabel
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@ast
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@en
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@nl
P2093
P356
P1433
P1476
Rescue of a deficiency in ATP ...... -encoded gene, to the nucleus.
@en
P2093
Eric A Schon
Giovanni Manfredi
James E Sadlock
Jennifer Q Kwong
Joseline Ojaimi
P2888
P304
P356
10.1038/NG851
P407
P577
2002-02-25T00:00:00Z