Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. - Wikidata - wikimedia - TriplyDB

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

http://www.wikidata.org/entity/Q34126244

about

PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility Recent advances in understanding leptin signaling and leptin resistance Adipocytes: impact on tumor growth and potential sites for therapeutic intervention Central nervous control of energy and glucose balance: focus on the central melanocortin system Adipose tissue, diabetes and Chagas disease Leptin action in pubertal development: recent advances and unanswered questions Role of the hypothalamus in mediating protective effects of dietary restriction during aging Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state Cross-Talk between Metabolism and Reproduction: The Role of POMC and SF1 Neurons Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons.PET imaging of leptin biodistribution and metabolism in rodents and primates.Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression WNK1 kinase balances T cell adhesion versus migration in vivo Unraveling the genetics of human obesity.Analysis of N-glycan in serum glycoproteins from db/db mice and humans with type 2 diabetes.Hypothalamic pathways linking energy balance and reproduction.Functional consequences of the human leptin receptor (LEPR) Q223R transversion.Leptin and the systems neuroscience of meal size control.Leptin receptor modulation of adiposity and fertility Utility of transplantation in studying adipocyte biogenesis and function Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis Melanocortin-3 receptors and metabolic homeostasis.Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development.Investigating the role of tbx4 in the female germline in mice.CNS leptin action modulates immune response and survival in sepsis.The lipoprivic control of feeding is governed by fat metabolism, not by leptin or adipose depletion.Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels Parameter adaptations during phenotype transitions in progressive diseases.Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.Tbx4 and tbx5 acting in connective tissue are required for limb muscle and tendon patterning Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons.The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

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Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

http://www.wikidata.org/entity/Q34126244

description

2005 nî lūn-bûn

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2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

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Journal of Clinical Investigation

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Complete rescue of obesity, di ...... on-specific LEPR-B transgenes.

@en

P2093

Carl de Luca

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Charlotte Lee

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Joel K Elmquist

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Manfred W Kilimann

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Shun-Mei Liu

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Streamson C Chua

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Thomas Ludwig

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Timothy J Kowalski

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Yiying Zhang

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P2860

Positional cloning of the mouse obese gene and its human homologue

The leptin receptor

Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Characterization of CART neurons in the rat and human hypothalamus.

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action.

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor.

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.

The need to feed: homeostatic and hedonic control of eating.

The role of leptin receptor signaling in feeding and neuroendocrine function.

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3484-3493

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10.1172/JCI24059

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12

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115

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16284652

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1280964

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