Translating Sleeping Beauty transposition into cellular therapies: victories and challenges. - Wikidata - wikimedia - TriplyDB

Translating Sleeping Beauty transposition into cellular therapies: victories and challenges.

Translating Sleeping Beauty transposition into cellular therapies: victories and challenges.

http://www.wikidata.org/entity/Q34127579

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The Sleeping Beauty transposon system: a non-viral vector for gene therapy CARs in chronic lymphocytic leukemia -- ready to drive A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19 A Broad Range of Dose Optima Achieve High-level, Long-term Gene Expression After Hydrodynamic Delivery of Sleeping Beauty Transposons Using Hyperactive SB100x Transposase DNA transposon-based gene vehicles - scenes from an evolutionary drive Engineered T cells for cancer treatment Genomic landscape of human, bat, and ex vivo DNA transposon integrations.Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells.Cellular immune response against firefly luciferase after sleeping beauty-mediated gene transfer in vivo Generation of a tumor- and tissue-specific episomal non-viral vector system.Ex vivo gene therapy for HIV-1 treatment.Lysosomal storage disease: gene therapy on both sides of the blood-brain barrier.Quantitative analysis of α-L-iduronidase expression in immunocompetent mice treated with the Sleeping Beauty transposon system The Drosophila gene disruption project: progress using transposons with distinctive site specificities.Mobilization of DNA transposable elements from lentiviral vectors.Treatment of phenylketonuria using minicircle-based naked-DNA gene transfer to murine liver.Anti-Tumor Effects after Adoptive Transfer of IL-12 Transposon-Modified Murine Splenocytes in the OT-I-Melanoma Mouse Model.Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells.Infusing CD19-directed T cells to augment disease control in patients undergoing autologous hematopoietic stem-cell transplantation for advanced B-lymphoid malignancies.Combination of Sleeping Beauty transposition and chemically induced dimerization selection for robust production of engineered cells.A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.Prospectives for gene therapy of retinal degenerations Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains.Antiangiogenic and Neurogenic Activities of Sleeping Beauty-Mediated PEDF-Transfected RPE Cells In Vitro and In Vivo Faster, cheaper, safer, T-cell engineering.New Strategies in Engineering T-cell Receptor Gene-Modified T cells to More Effectively Target Malignancies A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture.Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.Efficient sleeping beauty DNA transposition from DNA minicircles.Clinical application of Sleeping Beauty and artificial antigen presenting cells to genetically modify T cells from peripheral and umbilical cord blood.piggyBac transposase tools for genome engineering Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.Chimeric antibody receptors (CARs): driving T-cell specificity to enhance anti-tumor immunity Current treatment limitations in age-related macular degeneration and future approaches based on cell therapy and tissue engineering.Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids.Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies.The Sleeping Beauty transposon system for clinical applications.Recent developments in transposon-mediated gene therapy.

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Translating Sleeping Beauty transposition into cellular therapies: victories and challenges.

http://www.wikidata.org/entity/Q34127579

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2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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Laurence J N Cooper

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Perry B Hackett

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Zoltán Ivics

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Zsuzsanna Izsvák

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P2860

Mutational analysis of the N-terminal DNA-binding domain of sleeping beauty transposase: critical residues for DNA binding and hyperactivity in mammalian cells

Transposon-mediated genome manipulation in vertebrates

A transposon and transposase system for human application

Comparative analysis of transposable element vector systems in human cells

Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system

Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection

Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases

Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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