Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
about
Migrastatin analogues target fascin to block tumour metastasisSynthetic analogues of migrastatin that inhibit mammary tumor metastasis in miceMigrastatin analogues inhibit canine mammary cancer cell migration and invasionEvaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.Engineered production of iso-migrastatin in heterologous Streptomyces hosts.Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamidesSynthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactonesNitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural productsConvergent route to the spirohexenolide macrocycle.Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.Assessing the effects of adsorptive polymeric resin additions on fungal secondary metabolite chemical diversity.Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins.Multifaceted modes of action for the glutarimide-containing polyketides revealed.Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues.Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis.Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity.Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR.
P2860
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P2860
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
description
2002 nî lūn-bûn
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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
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2002年论文
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name
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@ast
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@en
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@nl
type
label
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@ast
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@en
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@nl
prefLabel
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@ast
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@en
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@nl
P2093
P1476
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
@en
P2093
Courtney M Starks
Elaine J Woo
John R Carney
Lawrence Cadapan
Peter Licari
Robert Arslanian
Stefan Zavala
P304
P577
2002-02-01T00:00:00Z