Obesity-linked variants of melanocortin-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone.
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Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsThe cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutantsBioanalysis of eukaryotic organellesA novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct foldingChaperoning G protein-coupled receptors: from cell biology to therapeuticsA small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivityFunctional studies on twenty novel naturally occurring melanocortin-4 receptor mutations.β-catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion.hMRAPα, but Not hMRAP2, Enhances hMC4R Constitutive Activity in HEK293 Cells and This Is Not Dependent on hMRAPα Induced Changes in hMC4R Complex N-linked Glycosylation.Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte-stimulating hormone (α-MSH).Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptinExposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize.Mild lipid stress induces profound loss of MC4R protein abundance and function.The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options.Latest approaches for the treatment of obesity.Leptin signalling pathways in hypothalamic neurons.Pathomechanistic characterization of two exonic L1CAM variants located in trans in an obligate carrier of X-linked hydrocephalus.Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene.Obesity Drug Update: The Lost Decade?Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases.Genetic variants help define the role of the MC4R C-terminus in signaling and cell surface stability.Glucose-regulated protein 78 binds to and regulates the melanocortin-4 receptor
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P2860
Obesity-linked variants of melanocortin-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@ast
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@en
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@nl
type
label
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@ast
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@en
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@nl
prefLabel
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@ast
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@en
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@nl
P2093
P2860
P921
P356
P1476
Obesity-linked variants of mel ...... rface by a chemical chaperone.
@en
P2093
Giulia Baldini
Ramanagouda Ramanagoudr-Bhojappa
Sameer Mohammad
Susana Granell
P2860
P304
P356
10.1210/ME.2010-0071
P577
2010-07-14T00:00:00Z