Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis - Wikidata - wikimedia - TriplyDB

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

http://www.wikidata.org/entity/Q24615395

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Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis Expanding proteostasis by membrane trafficking networks Molecular pathways for intracellular cholesterol accumulation: common pathogenic mechanisms in Niemann-Pick disease Type C and cystic fibrosis Protein homeostasis as a therapeutic target for diseases of protein conformation Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology Modulation of the maladaptive stress response to manage diseases of protein folding Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis The histone deacetylase inhibitor, Vorinostat, represses hypoxia inducible factor 1 alpha expression through translational inhibition Exploration of Novel Inhibitors for Class I Histone Deacetylase Isoforms by QSAR Modeling and Molecular Dynamics Simulation Assays Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model The cystic fibrosis transmembrane conductance regulator (CFTR) and its stability Enhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6.Endoplasmic reticulum-associated degradation of Niemann-Pick C1: evidence for the role of heat shock proteins and identification of lysine residues that accept ubiquitin.Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.Cystic fibrosis transmembrane conductance regulator protein repair as a therapeutic strategy in cystic fibrosis Applications of proteomic technologies for understanding the premature proteolysis of CFTR.Targets for cystic fibrosis therapy: proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulator Obesity-linked variants of melanocortin-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone.Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter.Neurology of inherited glycosylation disorders.A chaperone trap contributes to the onset of cystic fibrosis.A genomic signature approach to rescue ΔF508-cystic fibrosis transmembrane conductance regulator biosynthesis and function.Activation of the stress proteome as a mechanism for small molecule therapeutics.Pharmacological Correctors of Mutant CFTR Mistrafficking.Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells Targeted proteomic quantitation of the absolute expression and turnover of cystic fibrosis transmembrane conductance regulator in the apical plasma membrane.Long Non-coding RNA BGas Regulates the Cystic Fibrosis Transmembrane Conductance Regulator Emergent properties of proteostasis in managing cystic fibrosis.Histone deacetylases in skeletal development and bone mass maintenance.Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts.Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.Genetic therapies for cystic fibrosis lung disease Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.

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Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

http://www.wikidata.org/entity/Q24615395

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@ast

Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@en

Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@nl

type

label

Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@ast

Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@en

Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@nl

prefLabel

Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@ast

Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@en

Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@nl

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Nature Chemical Biology

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Reduced histone deacetylase 7 ...... folded CFTR in cystic fibrosis

@en

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Andre Schmidt

http://www.w3.org/2001/XMLSchema#string

Ben Hoch

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Darren M Hutt

http://www.w3.org/2001/XMLSchema#string

David Herman

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Eric J Sorscher

http://www.w3.org/2001/XMLSchema#string

Jeanne Matteson

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John R Riordan

http://www.w3.org/2001/XMLSchema#string

John R Yates

http://www.w3.org/2001/XMLSchema#string

Joseph M Pilewski

http://www.w3.org/2001/XMLSchema#string

Martina Gentzsch

http://www.w3.org/2001/XMLSchema#string

P2860

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Adapting proteostasis for disease intervention

Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo

Molecular basis of chronic inflammation in lung diseases: new therapeutic approach

The Sir2 family of protein deacetylases

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

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1721507

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10.1038/NCHEMBIO.275

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1

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6

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Gergely L Lukacs

Joel M. Gottesfeld

Tsukasa Okiyoneda

Jeffery W. Kelly

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2010-01-01T00:00:00Z

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40453743

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1050626048

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19966789

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cystic fibrosis

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2901172

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