Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat. - Wikidata - wikimedia - TriplyDB

Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.

Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.

http://www.wikidata.org/entity/Q34132686

about

Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy MicroRNA-regulated viral vectors for gene therapy miRNA therapeutics in cardiovascular diseases: promises and problems Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability.Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling Small and large animal models in cardiac contraction research: advantages and disadvantages MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.Gene delivery to the spinal cord using MRI-guided focused ultrasound A single direct injection into the left ventricular wall of an adeno-associated virus 9 (AAV9) vector expressing extracellular superoxide dismutase from the cardiac troponin-T promoter protects mice against myocardial infarction.Gene therapy delivery systems for enhancing viral and nonviral vectors for cardiac diseases: current concepts and future applications.Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution.Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis Oxidative stress decreases microtubule growth and stability in ventricular myocytes Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model.Comparative study of the transfection efficiency of commonly used viral vectors in rhesus monkey (Macaca mulatta) brains Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts Mitochondria-localized caveolin in adaptation to cellular stress and injury.Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer.The potential of adeno-associated viral vectors for gene delivery to muscle tissue.SERCA2a gene therapy can improve symptomatic heart failure in δ-sarcoglycan-deficient animals.AAV serotype influences gene transfer in corneal stroma in vivo.RH10 provides superior transgene expression in mice when compared with natural AAV serotypes for neonatal gene therapy.Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders Adeno-associated virus serotype 6 capsid tyrosine-to-phenylalanine mutations improve gene transfer to skeletal muscle.Safety and efficacy of high-dose adeno-associated virus 9 encoding sarcoplasmic reticulum Ca(2+) adenosine triphosphatase delivered by molecular cardiac surgery with recirculating delivery in ovine ischemic cardiomyopathy Mammalian models of Duchenne Muscular Dystrophy: pathological characteristics and therapeutic applications.The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models AAV vectors for cardiac gene transfer: experimental tools and clinical opportunities.Development of viral vectors for use in cardiovascular gene therapy.The evolution of heart gene delivery vectors Decreasing disease severity in symptomatic, Smn(-/-);SMN2(+/+), spinal muscular atrophy mice following scAAV9-SMN delivery Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy.MicroRNA therapeutics in cardiovascular medicine.

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Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.

http://www.wikidata.org/entity/Q34132686

description

2008 nî lūn-bûn

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2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Adeno-associated virus (AAV) s ...... and AAV8 in the mouse and rat.

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Adeno-associated virus (AAV) s ...... and AAV8 in the mouse and rat.

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Adeno-associated virus (AAV) s ...... and AAV8 in the mouse and rat.

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Adeno-associated virus (AAV) s ...... and AAV8 in the mouse and rat.

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Human Gene Therapy

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Adeno-associated virus (AAV) s ...... and AAV8 in the mouse and rat.

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Di Wu

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Guangping Gao

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H Lee Sweeney

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James M Wilson

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Julio Sanmiguel

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Kevin Morine

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Lawrence T Bish

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Meg M Sleeper

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P2860

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue

Clades of Adeno-associated viruses are widely disseminated in human tissues.

Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection.

Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8.

Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model

Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins.

Adeno-associated virus and the development of adeno-associated virus vectors: a historical perspective.

Targeting the heart with gene therapy-optimized gene delivery methods.

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1359-1368

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10.1089/HUM.2008.123

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12

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19

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23260677

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18795839

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2940566

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