A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.
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Optimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolitesKey Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate BiasHuman P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megateriumEconomical analysis of saturation mutagenesis experiments.Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids.Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity.Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivityAchieving regio- and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution.A Peroxygenase from Chaetomium globosum Catalyzes the Selective Oxygenation of Testosterone.Probing Steroidal Substrate Specificity of Cytochrome P450 BM3 Variants.Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme.Laboratory-Scale Hydroxylation of Steroids by P450BM3 Variants.CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity
P2860
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P2860
A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A single active site mutation ...... ngineered cytochrome P450 BM3.
@ast
A single active site mutation ...... ngineered cytochrome P450 BM3.
@en
A single active site mutation ...... ngineered cytochrome P450 BM3.
@nl
type
label
A single active site mutation ...... ngineered cytochrome P450 BM3.
@ast
A single active site mutation ...... ngineered cytochrome P450 BM3.
@en
A single active site mutation ...... ngineered cytochrome P450 BM3.
@nl
prefLabel
A single active site mutation ...... ngineered cytochrome P450 BM3.
@ast
A single active site mutation ...... ngineered cytochrome P450 BM3.
@en
A single active site mutation ...... ngineered cytochrome P450 BM3.
@nl
P2093
P2860
P356
P1433
P1476
A single active site mutation ...... ngineered cytochrome P450 BM3.
@en
P2093
Harini Venkataraman
Jan N M Commandeur
Laura A H van Bergen
Nick van Essen
Nico P E Vermeulen
Stephanie B A de Beer
P2860
P304
P356
10.1002/CBIC.201100750
P577
2012-01-24T00:00:00Z