A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability. - Wikidata - wikimedia - TriplyDB

A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability.

A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability.

http://www.wikidata.org/entity/Q34141795

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Gene therapy for the inner ear Beyond generalized hair cells: molecular cues for hair cell types Transcription Factors Expressed in Mouse Cochlear Inner and Outer Hair Cells Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development The regulation of gene expression in hair cells The quest for restoring hearing: Understanding ear development more completely.Targeted deletion of Sox10 by Wnt1-cre defects neuronal migration and projection in the mouse inner ear N-Myc and L-Myc are essential for hair cell formation but not maintenance Inner ear development: building a spiral ganglion and an organ of Corti out of unspecified ectoderm Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor Evolution and development of the tetrapod auditory system: an organ of Corti-centric perspective.Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system.Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear.The Role of Atonal Factors in Mechanosensory Cell Specification and Function Sox2-CreER mice are useful for fate mapping of mature, but not neonatal, cochlear supporting cells in hair cell regeneration studies.Atoh1 expression levels define the fate of rat cochlear nonsensory epithelial cells in vitro.Sensational placodes: neurogenesis in the otic and olfactory systems.The myc road to hearing restoration.Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.Filling the silent void: genetic therapies for hearing impairment.BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice.Regeneration of stereocilia of hair cells by forced Atoh1 expression in the adult mammalian cochlea.Lentivirus carrying the Atoh1 gene infects normal rat cochlea Continued expression of GATA3 is necessary for cochlear neurosensory development Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells.Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular context In vivo generation of immature inner hair cells in neonatal mouse cochleae by ectopic Atoh1 expression Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1.siRNA targeting Hes5 augments hair cell regeneration in aminoglycoside-damaged mouse utricle.Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti.Changes in ADF/destrin expression in the development of hair cells following Atoh1-induced ectopic regeneration.Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear.Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance Evolution of sound and balance perception: innovations that aggregate single hair cells into the ear and transform a gravistatic sensor into the organ of corti.The gene regulatory networks underlying formation of the auditory hindbrain.Atoh1 gene therapy in the cochlea for hair cell regeneration.

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A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability.

http://www.wikidata.org/entity/Q34141795

description

2012 nî lūn-bûn

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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2012 թվականի հունվարին հրատարակված գիտական հոդված

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2012年の論文

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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A novel Atoh1 "self-terminatin ...... differentiation and viability.

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Benjamin Kopecky

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Israt Jahan

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Jennifer Kersigo

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Jeremy S Duncan

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Ning Pan

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P2860

Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer.

Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation

Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier

Barhl1 regulatory sequences required for cell-specific gene expression and autoregulation in the inner ear and central nervous system

FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis

Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention

The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination

Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation

Math1: an essential gene for the generation of inner ear hair cells

Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene

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