Loss of normal huntingtin function: new developments in Huntington's disease research.
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Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in AplysiaHuntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its traffickingCongenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineagesCAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroupStimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2Connecting the dots in Huntington's disease with protein interaction networksThe predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factorThe P42 peptide and Peptide-based therapies for Huntington's diseaseModeling neurological disorders by human induced pluripotent stem cellsGenetics and neuropathology of Huntington's diseaseDeficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideumExpression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cellsHuntingtin and its role in neuronal degenerationNormal huntingtin function: an alternative approach to Huntington's diseaseHuntington's disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcriptionHuntington's diseaseSlitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in miceThe long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's diseaseTargeting several CAG expansion diseases by a single antisense oligonucleotideSynchrotron infrared microspectroscopy detecting the evolution of Huntington's disease neuropathology and suggesting unique correlates of dysfunction in white versus gray brain matter.Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.Brain Diffusivity and Structural Changes in the R6/2 Mouse Model of Huntington Disease.Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease?Therapeutic Strategies in Huntington's DiseaseEffects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicitySpecificity in intracellular protein aggregation and inclusion body formation.Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6Does apoptosis have a role in neurodegeneration?The domains of apoptosis: a genomics perspective.Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease.Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment.Comparison of modules of wild type and mutant Huntingtin and TP53 protein interaction networks: implications in biological processes and functions.Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.HD CAG-correlated gene expression changes support a simple dominant gain of function.Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients.Characterization of protein cross-links via mass spectrometry and an open-modification search strategy.Calcium Handling by Endoplasmic Reticulum and Mitochondria in a Cell Model of Huntington's Disease.
P2860
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P2860
Loss of normal huntingtin function: new developments in Huntington's disease research.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Loss of normal huntingtin function: new developments in Huntington's disease research.
@ast
Loss of normal huntingtin function: new developments in Huntington's disease research.
@en
Loss of normal huntingtin function: new developments in Huntington's disease research.
@nl
type
label
Loss of normal huntingtin function: new developments in Huntington's disease research.
@ast
Loss of normal huntingtin function: new developments in Huntington's disease research.
@en
Loss of normal huntingtin function: new developments in Huntington's disease research.
@nl
prefLabel
Loss of normal huntingtin function: new developments in Huntington's disease research.
@ast
Loss of normal huntingtin function: new developments in Huntington's disease research.
@en
Loss of normal huntingtin function: new developments in Huntington's disease research.
@nl
P2093
P50
P1476
Loss of normal huntingtin function: new developments in Huntington's disease research.
@en
P2093
D Goffredo
D Rigamonti
P304
P356
10.1016/S0166-2236(00)01721-5
P577
2001-03-01T00:00:00Z