Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain - Wikidata - wikimedia - TriplyDB

Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain

Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain

http://www.wikidata.org/entity/Q34146095

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Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review Structural Insights into the Assembly of CARMA1 and BCL10 Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181 Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.Essential gene profiles in breast, pancreatic, and ovarian cancer cells.Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.Gain-of-function mutations and immunodeficiency: at a loss for proper tuning of lymphocyte signaling.Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.NF-κB and cancer: a paradigm of Yin-Yang.NF-κB signaling pathways regulated by CARMA family of scaffold proteins.Germline CARD11 Mutation in a Patient with Severe Congenital B Cell Lymphocytosis.Regulation of NF-κB by the CARD proteins Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements.Intramolecular Interactions and Regulation of Cofactor Binding by the Four Repressive Elements in the Caspase Recruitment Domain-containing Protein 11 (CARD11) Inhibitory Domain.A new look at T cell receptor signaling to nuclear factor-κB Synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model.Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma.From MALT lymphoma to the CBM signalosome: three decades of discovery.The role of CARMA1 in T cells.Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies.Activating somatic mutations in diffuse large B-cell lymphomas: lessons from next generation sequencing and key elements in the precision medicine era.Molecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art.Rewired NFκB signaling as a potentially actionable feature of activated B-cell-like diffuse large B-cell lymphoma.Probes to monitor activity of the paracaspase MALT1.A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival.Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions.Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease Clinical and Genetic Heterogeneity of Mutations in Psoriatic Skin Disease

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P2860

Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain

http://www.wikidata.org/entity/Q34146095

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@ast

Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@en

Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@nl

type

label

Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@ast

Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@en

Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@nl

prefLabel

Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@ast

Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@en

Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@nl

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Oncogenic CARD11 mutations ind ...... C-responsive inhibitory domain

@en

P2093

Joel L Pomerantz

http://www.w3.org/2001/XMLSchema#string

Rebecca L Lamason

http://www.w3.org/2001/XMLSchema#string

Ryan R McCully

http://www.w3.org/2001/XMLSchema#string

Stefanie M Lew

http://www.w3.org/2001/XMLSchema#string

P2860

Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

Phosphorylation of the CARMA1 linker controls NF-kappaB activation

Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex.

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation

Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation

Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

Differential requirement for Malt1 in T and B cell antigen receptor signaling

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8240-8250

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scholarly article

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10.1021/BI101052D

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38

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49

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2010-09-01T00:00:00Z

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46034052

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20799731

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2943563

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