The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity - Wikidata - wikimedia - TriplyDB

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

http://www.wikidata.org/entity/Q34154475

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Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Mitochondrial dysfunction and oxidative stress in Parkinson's disease Evaluation of traditional medicines for neurodegenerative diseases using Drosophila models Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons Structural Asymmetry in the Closed State of Mitochondrial Hsp90 (TRAP1) Supports a Two-Step ATP Hydrolysis Mechanism Mitochondrial stress signaling promotes cellular adaptations Heat shock proteins in neurodegenerative disorders and aging Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks.Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila.TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila.NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cells High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model.Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function.Differential submitochondrial localization of PINK1 as a molecular switch for mediating distinct mitochondrial signaling pathways.Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer.TRAP1 rescues PINK1 loss-of-function phenotypes.α-Synuclein and mitochondria: partners in crime?Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.Insights into mitochondrial quality control pathways and Parkinson's disease.Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease.A mitocentric view of Parkinson's disease.Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues.Cellular models for Parkinson's disease.Mitochondrial control of cell bioenergetics in Parkinson's disease.Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells.The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells.Control of cell differentiation by mitochondria, typically evidenced in dictyostelium development.Cellular Signature of SIL1 Depletion: Disease Pathogenesis due to Alterations in Protein Composition Beyond the ER Machinery.αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease.Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology.Drosophila as a screening tool to study human neurodegenerative diseases.Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.

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The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

http://www.wikidata.org/entity/Q34154475

description

2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

@ast

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

@en

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

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type

label

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

@ast

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

@en

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

@nl

prefLabel

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

@ast

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

@en

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

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JOURNAL.PGEN.1002488

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The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

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A Kathrin Lutz

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Aaron Voigt

http://www.w3.org/2001/XMLSchema#string

Andrea Reinartz

http://www.w3.org/2001/XMLSchema#string

Ellen Gerhardt

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Erin K Butler

http://www.w3.org/2001/XMLSchema#string

Jane P Toegel

http://www.w3.org/2001/XMLSchema#string

Peter Karsten

http://www.w3.org/2001/XMLSchema#string

P2860

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila

TDP-43-mediated neuron loss in vivo requires RNA-binding activity

alpha-Synuclein locus triplication causes Parkinson's disease

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10.1371/JOURNAL.PGEN.1002488

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2

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8

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Konstanze F Winklhofer

Bjoern H Falkenburger

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2012-02-02T00:00:00Z

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221818312

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molecular chaperones

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3271059

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