Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. - Wikidata - wikimedia - TriplyDB

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

http://www.wikidata.org/entity/Q34156402

about

Acetylation-dependent oncogenic activity of metastasis-associated protein 1 co-regulator A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling Distinct requirements for the Sprouty domain for functional activity of Spred proteins Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1 The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance Fibroblast growth factor signaling in skeletal development and disease Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers Negative feedback regulation of the ERK1/2 MAPK pathway Patient-derived tumour xenografts for breast cancer drug discovery A functional interaction between sprouty proteins and caveolin-1 The NPAS3 gene--emerging evidence for a role in psychiatric illness Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model Systematic identification of genomic markers of drug sensitivity in cancer cells Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.Altered expression of miR-181a and miR-146a does not change the expression of surface NCRs in human NK cells.Regulation of sprouty stability by Mnk1-dependent phosphorylation.Control of the segmentation process by graded MAPK/ERK activation in the chick embryo.Gene expression responses to mechanical stimulation of mesenchymal stem cells seeded on calcium phosphate cement A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain The VASP-Spred-Sprouty domain puzzle.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor.HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.CtBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.TGF-β-mediated sustained ERK1/2 activity promotes the inhibition of intracellular growth of Mycobacterium avium in epithelioid cells surrogates.The developing story of Sprouty and cancer.Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries.

P2860

Q24292880-F5D2F8BC-D869-426F-B792-71D387BC95E4 Q24299217-3BA37FBA-E163-460B-95BB-64DD477FFEF3 Q24303940-12580B85-DF61-4EFC-AFFC-E27F19E0F39B Q24305529-FC93A2C6-CBF8-4F59-8A19-F33B58376F41 Q24324825-5E609B29-6639-49FF-9FB5-F76B5EF4BDAF Q24529002-4B906320-9060-49FB-8D94-9331DEF228C5 Q24630540-FF9A382A-6E25-46C8-B976-86B510B30A1A Q24685178-073D8681-0BF9-4B76-AFE7-3B0E89DE8862 Q26747247-677866E6-F8E1-4AF9-B996-67D426EF34F3 Q26771192-23A191A7-20AD-4095-BEE2-81A73453E8BB Q26795609-CB3C08FC-0A0F-4D29-A35D-C290342CC131 Q26798215-29967A6F-751C-465C-9899-3875921853EE Q26852269-91E2175B-8A86-45FC-97DD-CAE20983C88B Q26998955-C43CEFCF-58A7-4574-9F0E-99DF7DD0DF3C Q28079202-6055BE73-3B67-4CAD-ACFE-4F073C3B9B88 Q28080046-842D4796-4A7B-4F61-A2F8-FA0D3D24590C Q28254941-E5B9B58E-D1AB-4B25-8C02-64CCF082ED50 Q28265950-7C756108-76BD-447E-A311-4819A3A7BC5D Q28508257-DB248668-ACDE-4ACF-8566-454240B87469 Q28647819-20E5863F-636D-4E58-B232-03C8B8EC0759 Q29547695-522F3544-868C-4DFD-A22D-E258646AD0F6 Q30156817-5142B276-C986-481A-A8A8-90931D6A41E3 Q30157305-19965BFE-7553-439D-9459-77CEE1A7511A Q30364263-83A770DB-4FD0-4182-AC67-F59CC47FB18F Q30446670-751FB08A-0403-4699-887D-996FC6B4310D Q30476074-43AD273D-AB86-431A-A1DE-5BDCEA27F62A Q30554314-EE516965-4FCD-4636-A80D-8C7F7582EE5F Q30559743-572A1343-47DF-41BC-BAD6-83E73B7F1D27 Q33343173-3EFBB578-BCCB-453E-98CF-E89BF07CBF65 Q33364397-BD827940-0077-4E04-BCDD-9886845E8952 Q33566681-8223A8FF-F2A1-49E5-8C14-AFE556A1769E Q33581236-017FBC25-B629-4835-A487-66E2DD8FEA20 Q33636625-C7FA3614-C5CB-4386-9006-30F1CDFC8647 Q33692471-3E01C29D-2F26-46A6-A358-B8D9DBF13918 Q33725465-03EC28DB-4EF1-4DD7-B629-D861D6174590 Q33952468-26D6DEBC-7E6C-4D65-BA2C-4DC7CD6733EB Q33962853-71FC4EEF-6F3F-47D2-ABFC-E4089A3CEFE2 Q33971120-8E3716C9-69A0-4C63-9790-2D5505798945 Q34000521-CEA91C5D-D391-4409-934C-0831E2E5AC75 Q34000526-B01435A1-7D05-4E5A-8BB9-E47D3883CAA8

P2860

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

http://www.wikidata.org/entity/Q34156402

description

2002 nî lūn-bûn

@nan

2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@ast

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@en

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@nl

type

label

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@ast

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@en

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@nl

prefLabel

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@ast

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@en

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@nl

P1433

Q34156402-BABDFBE7-61FC-42CF-A868-806B7D9BDA02

P1476

Q34156402-DEE6C8F6-3551-4FDA-B63E-0DB2495CE8E8

P2093

Q34156402-452EE26F-BA89-4D61-A269-1EEFA1808D76

Q34156402-832A5E8E-B2BD-4507-9865-5A6ECDD9BFF1

Q34156402-8CADFAD8-FA43-497B-98CE-EF896CA23FB1

Q34156402-C8DE066F-CAC6-400D-A72D-9DF30C9FBC47

P2860

Q34156402-0654A2BB-6F84-42DB-B7F0-6FC98C7BC0C7

Q34156402-0C995323-C190-44BA-9494-37C4B2DB4158

Q34156402-1D1C21BC-E03A-4815-876B-AF51FF21B749

Q34156402-1FA6016A-73AA-47EB-95BA-DFAC9957C41B

Q34156402-215D433C-72A2-4EFD-A74B-A3B08F99E8BC

Q34156402-256B1B99-A493-4B9C-948A-1F5C2A55E4EA

Q34156402-25DDDA48-DD6B-4963-A975-811ACE038843

Q34156402-27328738-B972-45B2-A055-38D62436A22A

Q34156402-2B44803E-681B-4549-AC60-2AFBCA0CB9E6

Q34156402-42BFE2B9-40AD-4F01-825E-C570A75C80F1

P2888

Q34156402-9AE6CB0C-63BD-4C62-A0C0-94DD0965635B

P304

Q34156402-F604C550-E2E4-4A32-9FAB-271F3F3C3322

P31

Q34156402-3D902EE8-69F4-4657-AA74-6E7E102F5871

P356

Q34156402-AC81C796-BE2A-4F7F-BDCA-A33EF6ABC57B

P433

Q34156402-58B99D67-6FDE-46C1-9384-0F3BD812F577

P478

Q34156402-D1EE2910-664B-4DA4-AC8F-1FCEC52F2A4D

P577

Q34156402-16E30209-4CB5-4BF6-BD78-29694775BD3E

P5875

Q34156402-4269FFB6-DB60-4FA6-A338-2B9E7AC95DBF

P6179

Q34156402-FD51AE6E-F515-42B7-9A6A-3074640B6ACD

P698

Q34156402-35F22238-32B2-47E4-9178-42ACAE051DD1

P356

P1433

Nature Cell Biology

P1476

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

@en

P2093

Eisuke Nishida

http://www.w3.org/2001/XMLSchema#string

Hiroshi Hanafusa

http://www.w3.org/2001/XMLSchema#string

Satoru Torii

http://www.w3.org/2001/XMLSchema#string

Takayuki Yasunaga

http://www.w3.org/2001/XMLSchema#string

P2860

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

Cell signaling by receptor tyrosine kinases

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain

Evidence for direct interaction between Sprouty and Cbl

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

Negative regulation of cytokine signaling pathways

P2888

P304

850-858

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NCB867

http://www.w3.org/2001/XMLSchema#string

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

4

http://www.w3.org/2001/XMLSchema#string

P577

2002-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

11061927

http://www.w3.org/2001/XMLSchema#string

P6179

1021564861

http://www.w3.org/2001/XMLSchema#string

P698

12402043

http://www.w3.org/2001/XMLSchema#string