Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours - Wikidata - wikimedia - TriplyDB

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

http://www.wikidata.org/entity/Q34157777

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Energy metabolism in neuroblastoma and Wilms tumor RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action MicroRNAs in the pathogenesis of cystic kidney disease MicroRNA biogenesis pathways in cancer microRNA Therapeutics in Cancer - An Emerging Concept Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study.Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma Comparative methylome analysis identifies new tumour subtypes and biomarkers for transformation of nephrogenic rests into Wilms tumour The yin and yang of kidney development and Wilms' tumors Multiple mechanisms of MYCN dysregulation in Wilms tumour.The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities Genome-wide annotation of microRNA primary transcript structures reveals novel regulatory mechanisms High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer.p53 genes function to restrain mobile elements Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in DICER1 syndrome: a unique variant of the two-hit tumor suppression model.Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors.Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.Combining miRNA and mRNA Expression Profiles in Wilms Tumor Subtypes.Chromosomal anomalies at 1q, 3, 16q, and mutations of SIX1 and DROSHA genes underlie Wilms tumor recurrences Genetic variation frequencies in Wilms' tumor: A meta-analysis and systematic review The modulation of Dicer regulates tumor immunogenicity in melanoma.Dysregulation of microRNA biogenesis machinery in cancer.IsomiR expression patterns in canonical and Dicer‑independent microRNAs Dysregulation of microRNA biogenesis and gene silencing in cancer.Biomarkers to detect Wilms tumors in pediatric patients: where are we now?Anaplastic sarcomas of the kidney are characterized by DICER1 mutations.Genetic and epigenetic alterations of microRNAs and implications for human cancers and other diseases.Bilateral Wilms tumour: a review of clinical and molecular features.Lin28: an emerging important oncogene connecting several aspects of cancer.The genetic factors contributing to the development of Wilm's tumor and their clinical utility in its diagnosis and prognosis.MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours.Gene Silencing by RNAi in Mammalian Cells.Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.A comprehensive overview of computational resources to aid in precision genome editing with engineered nucleases.A network-biology perspective of microRNA function and dysfunction in cancer.The epigenetic landscape of renal cancer.Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.DGCR8 is essential for tumor progression following PTEN loss in the prostate.New roles for Dicer in the nucleolus and its relevance to cancer

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Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

http://www.wikidata.org/entity/Q34157777

description

2014 nî lūn-bûn

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2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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Somatic mutations in DROSHA an ...... ct mechanisms in Wilms tumours

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Somatic mutations in DROSHA an ...... ct mechanisms in Wilms tumours

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Somatic mutations in DROSHA an ...... ct mechanisms in Wilms tumours

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Somatic mutations in DROSHA an ...... ct mechanisms in Wilms tumours

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Somatic mutations in DROSHA an ...... ct mechanisms in Wilms tumours

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Somatic mutations in DROSHA an ...... ct mechanisms in Wilms tumours

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Nature Communications

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Somatic mutations in DROSHA an ...... ct mechanisms in Wilms tumours

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Abhay A Shukla

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Dinesh Rakheja

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James F Amatruda

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James S Malter

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Jonathan E Wickiser

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Joshua T Mendell

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Shama Khokhar

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Tsung-Cheng Chang

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Vanessa Schmid

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Yangjian Liu

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The nuclear RNase III Drosha initiates microRNA processing

The role of PACT in the RNA silencing pathway

The Drosha-DGCR8 complex in primary microRNA processing

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage

The widespread regulation of microRNA biogenesis, function and decay

Site-specific DICER and DROSHA RNA products control the DNA-damage response

let-7 microRNAs in development, stem cells and cancer

Structural basis for double-stranded RNA processing by Dicer

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10.1038/NCOMMS5802

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2

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Nitin J Karandikar

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2014-09-05T00:00:00Z

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265394867

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