Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.
about
TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeatsSpecific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complexRole of Tax protein in human T-cell leukemia virus type-I leukemogenicityNF-κB, the first quarter-century: remarkable progress and outstanding questionsHTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin ChainsMove or die: the fate of the Tax oncoprotein of HTLV-1.Proapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-kappaB pathway.X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production.NF-κB as a target for oncogenic viruses.Regulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway.Probing kinase activation and substrate specificity with an engineered monomeric IKK2A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation.Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.Mitochondrial targeting of growth suppressor protein DLC2 through the START domain.Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization.A 10-amino acid domain within human T-cell leukemia virus type 1 and type 2 tax protein sequences is responsible for their divergent subcellular distribution.The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains.Evidence for M1-Linked Polyubiquitin-Mediated Conformational Change in NEMO.
P2860
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P2860
Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.
description
2002 nî lūn-bûn
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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@ast
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@en
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@nl
type
label
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@ast
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@en
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@nl
prefLabel
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@ast
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@en
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@nl
P2093
P2860
P1433
P1476
Stimulation of IKK-gamma oligo ...... eukemia virus oncoprotein Tax.
@en
P2093
Dong Yan Jin
Guo Jin Huang
Zhi Qing Zhang
P2860
P304
P356
10.1016/S0014-5793(02)03590-1
P407
P577
2002-11-01T00:00:00Z