A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation. - Wikidata - wikimedia - TriplyDB

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

http://www.wikidata.org/entity/Q34159735

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Nuclear receptors in bone physiology and diseases The development of a bone- and parathyroid-specific analog of vitamin D: 2-methylene-19-Nor-(20S)-1α,25-dihydroxyvitamin D3.c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice.Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D₃ markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription.Effects of multi-deficiencies-diet on bone parameters of peripheral bone in ovariectomized mature rat Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling.Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers Vitamin D metabolism, mechanism of action, and clinical applications Ligand-specific structural changes in the vitamin D receptor in solution.Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3.A 20S combined with a 22R configuration markedly increases both in vivo and in vitro biological activity of 1α,25-dihydroxy-22-methyl-2-methylene-19-norvitamin D3 Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates.26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D3 compounds selectively active on intestine.Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1α,25-dihydroxyvitamin D3 Markedly Increases Bone Calcium Mobilization in Vivo.Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity.New insights into the mechanisms involved in the pleiotropic actions of 1,25dihydroxyvitamin D3.Semaphorin 3B is a 1,25-Dihydroxyvitamin D3-induced gene in osteoblasts that promotes osteoclastogenesis and induces osteopenia in mice Vitamin D and periodontal health: Current concepts.Therapeutic applications for novel non-hypercalcemic vitamin D receptor ligands.A new role for vitamin D receptor activation in chronic kidney disease.Vitamin D endocrine system and osteoblasts.Recent developments of 19-nor-1,25-dihydroxyvitamin D3 analogues.Triennial Growth Symposium--Vitamin D: bones and beyond.Vitamin D and gene networks in human osteoblasts.Phosphorylation of Human Retinoid X Receptor α at Serine 260 Impairs Its Subcellular Localization, Receptor Interaction, Nuclear Mobility, and 1α,25-Dihydroxyvitamin D3-dependent DNA Binding in Ras-transformed Keratinocytes.2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts.Identification of the vitamin D receptor in osteoblasts and chondrocytes but not osteoclasts in mouse bone.Total parathyroidectomy with forearm autotransplantation as the treatment of choice for secondary hyperparathyroidism.Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications.Pharmacokinetics of a New Oral Vitamin D Receptor Activator (2-Methylene-19-Nor-(20S)-1α,25-Dihydroxyvitamin D3) in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism on Hemodialysis.International congress on hormonal steroids and hormones in cancer.Models of Bone Remodelling and Associated Disorders

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P2860

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

http://www.wikidata.org/entity/Q34159735

description

2002 nî lūn-bûn

@nan

2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

@ast

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

@en

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

@nl

type

label

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

@ast

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

@en

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

@nl

prefLabel

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

@ast

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

@en

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

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Proceedings of the National Academy of Sciences of the United States of America

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A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

@en

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Hector F DeLuca

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Hironori Yamamoto

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J Wesley Pike

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Lori A Plum

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Margaret Clagett-Dame

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Nirupama K Shevde

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P2860

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription.

Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression.

Biological activity of 25-hydroxycholecalciferol, a metabolite of vitamin D3.

Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene.

New 1alpha,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues.

The transformation of a vitamin into a hormone: the vitamin D story.

A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1beta, TNF-alpha, PTH, PTHrP, and 1, 25(OH)2D3.

Vitamin D is not directly necessary for bone growth and mineralization.

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13487-13491

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scholarly article

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10.1073/PNAS.202471299

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21

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99

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2002-10-08T00:00:00Z

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11084900

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12374862

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129700

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