Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.
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Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D₃ markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription.Inhibitors for the Vitamin D Receptor-Coregulator Interaction.A 20S combined with a 22R configuration markedly increases both in vivo and in vitro biological activity of 1α,25-dihydroxy-22-methyl-2-methylene-19-norvitamin D326-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D3 compounds selectively active on intestine.A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1α,25-dihydroxyvitamin D3 Markedly Increases Bone Calcium Mobilization in Vivo.Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase.26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo.
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P2860
Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.
description
2008 nî lūn-bûn
@nan
2008年の論文
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2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Synthesis and biological prope ...... 26,23-lactones--weak agonists.
@ast
Synthesis and biological prope ...... 26,23-lactones--weak agonists.
@en
type
label
Synthesis and biological prope ...... 26,23-lactones--weak agonists.
@ast
Synthesis and biological prope ...... 26,23-lactones--weak agonists.
@en
prefLabel
Synthesis and biological prope ...... 26,23-lactones--weak agonists.
@ast
Synthesis and biological prope ...... 26,23-lactones--weak agonists.
@en
P2093
P2860
P1476
Synthesis and biological prope ...... 26,23-lactones--weak agonists.
@en
P2093
Grazia Chiellini
Hector F DeLuca
Lori A Plum
Margaret Clagett-Dame
Pawel Grzywacz
Rafal Barycki
P2860
P304
P356
10.1016/J.BMC.2008.08.011
P407
P577
2008-08-07T00:00:00Z