53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.
about
The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayHuman PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiationThe cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cellsVaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damageInduction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stressPhospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damageHuman MMS21/NSE2 is a SUMO ligase required for DNA repairArtemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint responseHuman Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpointThe role of dicer in DNA damage repairComparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysisOrchestration of the DNA-damage response by the RNF8 ubiquitin ligaseHistone deacetylase 4 interacts with 53BP1 to mediate the DNA damage responseFunctional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestTP53-binding protein variants and breast cancer risk: a case-control studyMicrowaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy personsMultiple facets of p53 in senescence induction and maintenanceTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy53BP1: pro choice in DNA repairCrystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitorRole of DNA repair machinery and p53 in the testicular germ cell cancer: a reviewNFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damageMediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint controlAberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damageCounterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damage induction in lung cancersBRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageThe CHEK2 gene and inherited breast cancer susceptibilityEDD mediates DNA damage-induced activation of CHK2The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulationGenome stability pathways in head and neck cancersRole of cell cycle regulators in lung carcinogenesisAberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parametersA mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpointAn HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesisExpanded roles of the Fanconi anemia pathway in preserving genomic stability53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks53BP1 is required for class switch recombination.Activation of the DNA damage checkpoint and genomic instability in human precancerous lesionsThe yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence.
P2860
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P2860
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@ast
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@en
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@nl
type
label
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@ast
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@en
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@nl
prefLabel
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@ast
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@en
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@nl
P2093
P356
P1433
P1476
53BP1 functions in an ATM-depe ...... ely activated in human cancer.
@en
P2093
Maxwell Sehested
Monica Venere
Richard A DiTullio
Tamara A Mochan
Thanos D Halazonetis
P2888
P304
P356
10.1038/NCB892
P577
2002-12-01T00:00:00Z
P5875
P6179
1029003147