A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. - Wikidata - wikimedia - TriplyDB

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

http://www.wikidata.org/entity/Q34165508

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Guidelines for the use and interpretation of assays for monitoring autophagy Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons Autophagy in ageing and ageing-associated diseases Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)The neurology of mTOR Longitudinal measures of proteostasis in live neurons: features that determine fate in models of neurodegenerative disease Protein homeostasis as a therapeutic target for diseases of protein conformation Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach ATP13A2 regulates mitochondrial bioenergetics through macroautophagy Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1 High-throughput screening in primary neurons Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.Autophagy-regulating small molecules and their therapeutic applications.Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.Targeting intracellular degradation pathways for treatment of liver disease caused by α1-antitrypsin deficiency Targets for future clinical trials in Huntington's disease: what's in the pipeline?The biology of proteostasis in aging and disease.A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.Autophagy-mediated turnover of dynamin-related protein 1.Autophagy failure in Alzheimer's disease--locating the primary defect.Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells Identification of natural products with neuronal and metabolic benefits through autophagy induction.Lysosomal adaptation: How cells respond to lysosomotropic compounds.Tor1 regulates protein solubility in Saccharomyces cerevisiae.Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis Methylene blue induces macroautophagy through 5' adenosine monophosphate-activated protein kinase pathway to protect neurons from serum deprivation A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy Sonic hedgehog promotes autophagy in hippocampal neurons.Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases.Compartment-Specific Regulation of Autophagy in Primary Neurons.Disorders of protein misfolding: alpha-1-antitrypsin deficiency as prototype.

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A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

http://www.wikidata.org/entity/Q34165508

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

A small-molecule scaffold indu ...... in a Huntington disease model.

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A small-molecule scaffold indu ...... in a Huntington disease model.

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A small-molecule scaffold indu ...... in a Huntington disease model.

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A small-molecule scaffold indu ...... in a Huntington disease model.

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Proceedings of the National Academy of Sciences of the United States of America

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A small-molecule scaffold indu ...... in a Huntington disease model

@en

P2093

Andrey S Tsvetkov

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Jinny S Wong

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Michael A Pleiss

http://www.w3.org/2001/XMLSchema#string

Steven Finkbeiner

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

Autophagy fights disease through cellular self-digestion

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Hypothalamic mTOR signaling regulates food intake

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Methods in mammalian autophagy research

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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scholarly article

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10.1073/PNAS.1004498107

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39

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107

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Jason M L Miller

Montserrat Arrasate

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2010-09-10T00:00:00Z

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46220315

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20833817

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Huntington disease

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2947884

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