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Increased stability of the p16 mRNA with replicative senescence

Increased stability of the p16 mRNA with replicative senescence

http://www.wikidata.org/entity/Q34166682

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p16(INK4a) translation suppressed by miR-24 RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway CSIG inhibits PTEN translation in replicative senescence ING4 inhibits the translation of proto-oncogene MYC by interacting with AUF1 Identification of a signature motif in target mRNAs of RNA-binding protein AUF1 mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription A method for purification, identification and validation of DNMT1 mRNA binding proteins Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay.The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1.p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity AUF-1 and YB-1 independently regulate β-globin mRNA in developing erythroid cells through interactions with poly(A)-binding protein AUF1 cell cycle variations define genomic DNA methylation by regulation of DNMT1 mRNA stability Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer.Reactive oxygen species and hematopoietic stem cell senescence.Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells.The tRNA methyltransferase NSun2 stabilizes p16INK⁴ mRNA by methylating the 3'-untranslated region of p16 Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs.Modulation of neoplastic gene regulatory pathways by the RNA-binding factor AUF1 mRNA stability control: a clandestine force in normal and malignant hematopoiesis.A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression p16(INK4A) represses the paracrine tumor-promoting effects of breast stromal fibroblasts.Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence.The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts Modelling mammalian cellular quiescence.AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders.Turnover of AU-rich-containing mRNAs during stress: a matter of survival.The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells.RNA-binding proteins as molecular links between cancer and neurodegeneration.hnRNP C1/C2 and Pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang.Linking cell polarity, aging and rejuvenation.Increased expression of senescence markers p14(ARF) and p16(INK4a) in breast cancer is associated with an increased risk of disease recurrence and poor survival outcome.MicroRNA-141 and microRNA-146b-5p inhibit the prometastatic mesenchymal characteristics through the RNA-binding protein AUF1 targeting the transcription factor ZEB1 and the protein kinase AKT Molecular Regulation of Cellular Quiescence: A Perspective from Adult Stem Cells and Its Niches.p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1.CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1α

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P2860

Increased stability of the p16 mRNA with replicative senescence

http://www.wikidata.org/entity/Q34166682

description

2005 nî lūn-bûn

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2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի փետրվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Increased stability of the p16 mRNA with replicative senescence

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Increased stability of the p16 mRNA with replicative senescence

@en

Increased stability of the p16 mRNA with replicative senescence

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type

label

Increased stability of the p16 mRNA with replicative senescence

@ast

Increased stability of the p16 mRNA with replicative senescence

@en

Increased stability of the p16 mRNA with replicative senescence

@nl

prefLabel

Increased stability of the p16 mRNA with replicative senescence

@ast

Increased stability of the p16 mRNA with replicative senescence

@en

Increased stability of the p16 mRNA with replicative senescence

@nl

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Increased stability of the p16 mRNA with replicative senescence

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Francis J Chrest

http://www.w3.org/2001/XMLSchema#string

Jennifer L Martindale

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Wengong Wang

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Xiaoling Yang

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P2860

Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

HuR regulates p21 mRNA stabilization by UV light

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms

Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference

Gene expression profile of aging and its retardation by caloric restriction

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging.

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