A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.
about
A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3Potassium channel modulation by a toxin domain in matrix metalloprotease 23K+ channels as targets for specific immunomodulationThe voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MSThe D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferationTargeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseasesSynthesis of a biotin derivative of iberiotoxin: binding interactions with streptavidin and the BK Ca2+-activated K+ channel expressed in a human cell line.Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthmaA systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activationTargeting potassium channels Kv1.3 and KC a 3.1: routes to selective immunomodulators in autoimmune disorder treatment?Fluorescent system based on bacterial expression of hybrid KcsA channels designed for Kv1.3 ligand screening and study.HIV-1 Tat protein increases microglial outward K(+) current and resultant neurotoxic activity.Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY.N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases.Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteriaSelective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis modelA severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients.Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease.Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosusDifferent expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytesTight junctions potentiate the insulative properties of small CNS myelinated axons.K+ channel modulators for the treatment of neurological disorders and autoimmune diseasesA potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmationThe K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy.In vitro evaluation of functional interaction of integrin alphavbeta3 and matrix metalloprotease-2.Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.The functional network of ion channels in T lymphocytesProlonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 ChannelChanges in Gene Expression and Metabolism in the Testes of the Rat following Spinal Cord Injury.Inhibition of Kv1.3 potassium current by phosphoinositides and stromal-derived factor-1alpha in Jurkat T cells.Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4+ T Cells.A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions.Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation.Kv1.3 blockers ameliorate allergic contact dermatitis by preferentially suppressing effector memory T cells in a rat model.A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3.Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish.
P2860
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P2860
A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@ast
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@en
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@nl
type
label
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@ast
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@en
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@nl
prefLabel
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@ast
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@en
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@nl
P2093
P2860
P356
P1476
A novel fluorescent toxin to d ...... cally activated T lymphocytes.
@en
P2093
Christine Beeton
George A Gutman
George Crossley
Heike Wulff
K George Chandy
Michael D Cahalan
Michael Pennington
Satendra Singh
Steve Botsko
P2860
P304
P356
10.1074/JBC.M212868200
P407
P577
2003-01-02T00:00:00Z