Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease
about
Pharmacological chaperone therapy for lysosomal storage diseases.The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef.Fungal Glycolipid Hydrolase Inhibitors and Their Effect on Cryptococcus neoformans.β-Glucosidase 2 (GBA2) activity and imino sugar pharmacology.Gaucher disease paradigm: from ERAD to comorbidity.Glucocerebrosidase inhibitors for the treatment of Gaucher disease.Pharmacological chaperones for enzyme enhancement therapy in genetic diseases.Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo.Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases.New Directions in Gaucher Disease.Glucosylceramide mimics: highly potent GCase inhibitors and selective pharmacological chaperones for mutations associated with types 1 and 2 Gaucher disease.Bicyclic derivatives of L-idonojirimycin as pharmacological chaperones for neuronopathic forms of Gaucher disease.Ambroxol as a pharmacological chaperone for mutant glucocerebrosidase.A systematic investigation of iminosugar click clusters as pharmacological chaperones for the treatment of Gaucher disease.New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease.Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier.Mass spectrometric study of gas-phase ions of acid β-glucosidase (Cerezyme) and iminosugar pharmacological chaperones.Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones.
P2860
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P2860
Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease
description
2012 nî lūn-bûn
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2012 թուականի Մարտին հրատարակուած գիտական յօդուած
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2012 թվականի մարտին հրատարակված գիտական հոդված
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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name
Rapid assembly of a library of ...... e treatment of Gaucher disease
@ast
Rapid assembly of a library of ...... e treatment of Gaucher disease
@en
Rapid assembly of a library of ...... e treatment of Gaucher disease
@nl
type
label
Rapid assembly of a library of ...... e treatment of Gaucher disease
@ast
Rapid assembly of a library of ...... e treatment of Gaucher disease
@en
Rapid assembly of a library of ...... e treatment of Gaucher disease
@nl
prefLabel
Rapid assembly of a library of ...... e treatment of Gaucher disease
@ast
Rapid assembly of a library of ...... e treatment of Gaucher disease
@en
Rapid assembly of a library of ...... e treatment of Gaucher disease
@nl
P2093
P2860
P356
P1476
Rapid assembly of a library of ...... e treatment of Gaucher disease
@en
P2093
Christina Tysoe
Don J Mahuran
Ethan D Goddard-Borger
Michael B Tropak
Sayuri Yonekawa
Stephen G Withers
P2860
P304
P356
10.1021/JM201633Y
P407
P577
2012-03-06T00:00:00Z