Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

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Sugar hydrazide imides: a new family of glycosidase inhibitors.Molecular basis of cystic fibrosis: from bench to bedside

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P2860

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

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Synthetic deoxynojirimycin der ...... ll as F508del-CFTR correctors.

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Synthetic deoxynojirimycin der ...... ll as F508del-CFTR correctors.

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Synthetic deoxynojirimycin der ...... ell as F508del-CFTR correctors

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P2860

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Molecular basis for trehalase inhibition revealed by the structure of trehalase in complex with potent inhibitors

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease

Molecular basis for inhibition of GH84 glycoside hydrolases by substituted azepanes: conformational flexibility enables probing of substrate distortion

Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

Understanding organofluorine chemistry. An introduction to the C-F bond

Amplification of the inhibitory activity and reversal of the selectivity of miglitol by C(2')-monofluorination.

Glycosidase inhibition with fullerene iminosugar balls: a dramatic multivalent effect.

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.

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Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

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P2860

P2860

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

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