Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens.
about
Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural ProductsChassis optimization as a cornerstone for the application of synthetic biology based strategies in microbial secondary metabolismMetabolomics methods for the synthetic biology of secondary metabolismLessons learned from the transformation of natural product discovery to a genome-driven endeavorHuman commensals producing a novel antibiotic impair pathogen colonizationExploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproductionCrp is a global regulator of antibiotic production in streptomycesPhage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene clusterExpanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pecCombinatorial biosynthesis of polyketides--a perspective.Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations.Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciensPortability and Structure of the Four-Helix Bundle Docking Domains of trans-Acyltransferase Modular Polyketide Synthases.Discovery research: the scientific challenge of finding new antibiotics.Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clustersTranscriptome mining of active biosynthetic pathways and their associated products in Streptomyces flaveolus.Mining the metabiome: identifying novel natural products from microbial communities.Genome mining of Streptomyces ambofaciens.Metagenomic small molecule discovery methods.A walk into the LuxR regulators of Actinobacteria: phylogenomic distribution and functional diversityThe Streptomyces leeuwenhoekii genome: de novo sequencing and assembly in single contigs of the chromosome, circular plasmid pSLE1 and linear plasmid pSLE2Culturable rare Actinomycetes: diversity, isolation and marine natural product discovery.Chemical probes for the functionalization of polyketide intermediates.Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis.Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.A comprehensive review of glycosylated bacterial natural products.Identification of novel mureidomycin analogues via rational activation of a cryptic gene cluster in Streptomyces roseosporus NRRL 15998.Using natural products for drug discovery: the impact of the genomics era.Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic InferenceMetabolic profiling as a tool for prioritizing antimicrobial compoundsIdentification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome MiningMolecular regulation of antibiotic biosynthesis in streptomyces.Identification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy.Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp.Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules.A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.Natural products and Pharma 2011: strategic changes spur new opportunities.Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.Ribosome-inactivating proteins with an emphasis on bacterial RIPs and their potential medical applications.
P2860
Q26752751-19A29ED6-5C9D-4697-BC4B-38AF80572161Q26781404-F81A6F11-F9C2-4E13-B44A-92C5EE7C7519Q26822396-080787B7-78AD-42F5-8ECF-3A2D510D58A6Q27007021-94392EB0-D64D-482B-A98B-85A28125F160Q28005468-DE79A65A-4332-4A02-9197-FF45623317D0Q28481642-1F67A2A4-876E-4E49-9BDD-0F7174ED51DEQ28504079-9D895193-85A5-43E5-92AB-6A066F38CDBDQ28534635-EE03877E-5400-4D7A-98C3-8CB93E1A3B94Q28545284-30FBB7DC-962E-48D9-8BB2-8AC4300DC020Q30413205-3C7D9BD2-CAA0-4C74-A63E-CB652D7B4308Q31140705-848EBC1B-AE04-4AC0-BE9F-83AE72F5003BQ33665576-828D5E09-B2EA-4238-8F82-6F16BA9DA770Q33768985-171F5532-901E-4D3B-851A-A4B404528A5BQ33941796-39C83F30-2A19-42AF-9CF5-A0FD53EB8610Q34010109-77BBDD62-4394-463C-B546-BA929CBE070BQ34219458-ACC7B736-3861-4909-87A8-D401315F2B88Q34228002-B92995D8-6B9B-4385-A296-07956D839A84Q34386573-D57F4B3E-C6F7-4004-BE31-779BAC398F4AQ34428178-7F0900BA-F985-4FDB-9433-9D0798A4A789Q34442064-1C367AA2-90C9-4726-BB18-5C78F316B21CQ34482803-2AF3BB02-5009-4CFD-AFBB-08876F2FFAF4Q34993999-1CF7F96B-765F-4DAA-882B-F3CF0A92B4E7Q35248736-311E3BFD-ECA9-471F-8A07-60AF86C09878Q35780235-B0510B49-9B6D-4F8F-A6BB-0616B5DA10A6Q35895616-094E2922-F29D-4FC2-B258-EA005208F8E7Q36029831-C21AB18F-BAEE-42FB-83AF-3C76222F3DDBQ36067939-AFA0FB69-6840-4756-B94C-F34C48F3B551Q36302104-9401B7A9-DEBE-4190-8AF6-56B8C866B843Q36316024-315B4F6C-57F0-45CA-917F-BDF246A1D0BAQ36577086-C192B520-6800-4FE1-A917-FE2FAFB24362Q36592709-B63B055B-F3CF-4CFD-B260-1790129791AEQ36667387-8F87E9D8-7ED7-47FA-9171-514CF22059D2Q36702895-6A6C8DFE-D97E-44F2-975F-8B11B819E20DQ37287146-F56A14A6-D9CE-46BC-AAF9-8520AF97EC4FQ37340715-658417B1-AA32-486D-B37B-8D4A91B699ACQ37533520-86D3A696-92D4-48DC-82A9-BFE40167277BQ37571513-E6287CEE-E731-422C-A1EC-B382BEA49658Q37930443-D31CEED0-CF68-44DA-BE55-63C91DC6BB87Q37962381-4F3BA166-B8B6-4EB2-80E7-506189FA1D41Q38019016-1F1ECF9C-AD3E-4199-80FE-F751DF5E75F3
P2860
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@ast
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@en
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@nl
type
label
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@ast
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@en
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@nl
prefLabel
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@ast
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@en
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@nl
P2860
P50
P356
P1476
Identification of a bioactive ...... e in Streptomyces ambofaciens.
@en
P2093
Lijiang Song
Sheng Huang
P2860
P304
P356
10.1073/PNAS.1019077108
P407
P577
2011-03-28T00:00:00Z