Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis.

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A synthetic pathway for the fixation of carbon dioxide in vitro.Extending Polyketide Structural Diversity by Using Engineered Carboxylase/Reductase Enzymes.A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters.InhA, the enoyl-thioester reductase from forms a covalent adduct during catalysis

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P2860

Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis.

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Screening and Engineering the ...... m and Polyketide Biosynthesis.

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Screening and Engineering the ...... m and Polyketide Biosynthesis.

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Screening and Engineering the ...... m and Polyketide Biosynthesis.

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Screening and Engineering the ...... sm and Polyketide Biosynthesis

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Dominik M Peter

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Lennart Schada von Borzyskowski

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Patrick Kiefer

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Philipp Christen

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P2860

Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway

Unusual carbon fixation gives rise to diverse polyketide extender units

Natural products as sources of new drugs over the 30 years from 1981 to 2010

Natural products version 2.0: connecting genes to molecules.

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens.

Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility.

A set of versatile brick vectors and promoters for the assembly, expression, and integration of synthetic operons in Methylobacterium extorquens AM1 and other alphaproteobacteria.

Demonstration of the ethylmalonyl-CoA pathway by using 13C metabolomics.

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.

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13457-13461

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scholarly article

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10.1002/ANIE.201505282

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English

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Julia Vorholt

Tobias J. Erb

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2015-09-18T00:00:00Z

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26383129

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Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis.

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P2860

P2860

Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis.

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