MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
about
Developmental Dynamics of Rett SyndromeMECP2 disorders: from the clinic to mice and backDNA modifications: function and applications in normal and disease StatesA role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment.The Crucial Role of DNA Methylation and MeCP2 in Neuronal FunctionDrosophila as a model for MECP2 gain of function in neurons.Chromatin modification by PSC occurs at one PSC per nucleosome and does not require the acidic patch of histone H2A.Direct homo- and hetero-interactions of MeCP2 and MBD2.Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions.The role of genetics in the establishment and maintenance of the epigenome.MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin.DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2).Chromatin higher-order structures and gene regulationSynaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities.MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain.A high-resolution imaging approach to investigate chromatin architecture in complex tissuesEpigenetic mechanisms in neurological diseaseImpaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domainA synonymous change, p.Gly16Gly in MECP2 Exon 1, causes a cryptic splice event in a Rett syndrome patient.From Function to Phenotype: Impaired DNA Binding and Clustering Correlates with Clinical Severity in Males with Missense Mutations in MECP2.Chromatin context and ncRNA highlight targets of MeCP2 in brain.The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site.Allele-specific DNA methylation: beyond imprinting.The role of methyl-binding proteins in chromatin organization and epigenome maintenance.Rett syndrome and MeCP2.Unusual characteristics of the DNA binding domain of epigenetic regulatory protein MeCP2 determine its binding specificity.Site-specific methylated reporter constructs for functional analysis of DNA methylation.Rett syndrome: a complex disorder with simple roots.Differential Regulation of MeCP2 Phosphorylation by Laminin in Oligodendrocytes.MECP2, a multi-talented modulator of chromatin architecture.Proteins That Read DNA Methylation.Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function.MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.Comparative analysis of linker histone H1, MeCP2, and HMGD1 on nucleosome stability and target site accessibility.Novel alterations in the epigenetic signature of MeCP2-targeted promoters in lymphocytes of Rett syndrome patients.DNA methylation effects on tetra-nucleosome compaction and aggregationIntegrative analysis of methylome and transcriptome reveals the importance of unmethylated CpGs in non-CpG island gene activation.RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome.
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P2860
MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@ast
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@en
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@nl
type
label
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@ast
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@en
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@nl
prefLabel
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@ast
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@en
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@nl
P2093
P2860
P356
P1476
MeCP2 binds cooperatively to i ...... H1 for chromatin binding sites
@en
P2093
Christopher L Woodcock
Luda S Shlyakhtenko
Rachel A Horowitz-Scherer
Tatiana Nikitina
P2860
P304
P356
10.1128/MCB.00379-10
P407
P577
2010-08-02T00:00:00Z