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Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters

http://www.wikidata.org/entity/Q34178349

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Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa Evolutionary dynamics of HIV at multiple spatial and temporal scales.The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.Molecular characterization of HIV-1 CRF01_AE in Mekong Delta, Vietnam, and impact of T-cell epitope mutations on HLA recognition (ANRS 12159).Impact of HLA selection pressure on HIV fitness at a population level in Mexico and Barbados.Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms.Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure.Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1.CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles.Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence.Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck.No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection.A restriction enzyme based cloning method to assess the in vitro replication capacity of HIV-1 subtype C Gag-MJ4 chimeric viruses.Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance Immune-mediated attenuation of HIV-1 Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity.Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals.Temporal association of HLA-B*81:01- and HLA-B*39:10-mediated HIV-1 p24 sequence evolution with disease progression.Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.Cumulative impact of host and viral factors on HIV-1 viral-load control during early infection Significant reductions in Gag-protease-mediated HIV-1 replication capacity during the course of the epidemic in Japan HLA-B*57 versus HLA-B*81 in HIV-1 infection: slow and steady wins the race?HIV-1 conserved-element vaccines: relationship between sequence conservation and replicative capacity Impact of pre-adapted HIV transmission.Immunogenetics of HIV disease.Influence of HLA-C expression level on HIV control Paediatric non-progression following grandmother-to-child HIV transmission Differential escape patterns within the dominant HLA-B*57:03-restricted HIV Gag epitope reflect distinct clade-specific functional constraints.Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity.

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Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters

http://www.wikidata.org/entity/Q34178349

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Gag-protease-mediated replicat ...... A type and clinical parameters

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Gag-protease-mediated replicat ...... A type and clinical parameters

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Journal of Virology

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Gag-protease-mediated replicat ...... A type and clinical parameters

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Bingxia Wang

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Carl M Kadie

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Fundisiwe Chonco

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Jaclyn K Wright

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Jonathan M Carlson

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Toshiyuki Miura

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P2860

Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response

Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1

Statistical significance for genomewide studies

The influence of HLA genotype on AIDS

Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).

Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.

Abundance of early functional HIV-specific CD8+ T cells does not predict AIDS-free survival time.

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate

Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.

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10820-10831

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scholarly article

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10.1128/JVI.01084-10

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P433

20

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84

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Bruce D. Walker

Chanson J Brumme

Mark A. Brockman

Karen S. Bishop

Zabrina L Brumme

Philip J. R. Goulder

Mary van der Stok

P577

2010-08-11T00:00:00Z

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45629542

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20702636

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2950592

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