Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
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Role of HLA Adaptation in HIV EvolutionThe fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.Impact of HLA selection pressure on HIV fitness at a population level in Mexico and Barbados.Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design.Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation.Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients.A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection.A restriction enzyme based cloning method to assess the in vitro replication capacity of HIV-1 subtype C Gag-MJ4 chimeric viruses.Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo.The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers.Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals.Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C.Temporal association of HLA-B*81:01- and HLA-B*39:10-mediated HIV-1 p24 sequence evolution with disease progression.Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.Frequent and variable cytotoxic-T-lymphocyte escape-associated fitness costs in the human immunodeficiency virus type 1 subtype B Gag proteins.HLA-B*57 versus HLA-B*81 in HIV-1 infection: slow and steady wins the race?HIV-1 conserved-element vaccines: relationship between sequence conservation and replicative capacityImpact of pre-adapted HIV transmission.Pressure from TRIM5α contributes to control of HIV-1 replication by individuals expressing protective HLA-B alleles.Paediatric non-progression following grandmother-to-child HIV transmissionBalance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression.Dynamics and Correlates of CD8 T-Cell Counts in Africans with Primary Human Immunodeficiency Virus Type 1 Infection.Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity.Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression.Early evolution of human leucocyte antigen-associated escape mutations in variable Gag proteins predicts CD4+ decline in HIV-1 subtype C-infected women.Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape.Maintenance of AP-2 Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses.High-Resolution Sequencing of Viral Populations During Early SIV Infection Reveals Evolutionary Strategies for Rapid Escape from Emerging Env-Specific Antibody Responses.Rapid HIV disease progression following superinfection in an HLA-B*27:05/B*57:01-positive transmission recipient.Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection
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P2860
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
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2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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2012年论文
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name
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
@ast
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
@en
type
label
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
@ast
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
@en
prefLabel
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
@ast
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
@en
P2093
P2860
P50
P356
P1433
P1476
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
@en
P2093
Daniel T Claiborne
Eric Hunter
Jaclyn K Wright
Jessica L Prince
Philip J R Goulder
Vanessa L Naidoo
P2860
P304
P356
10.1128/JVI.06682-11
P407
P577
2012-01-11T00:00:00Z