Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues
about
Novel therapeutic strategies targeting HIV integraseThe three-dimensional structure of a Tn5 transposase-related protein determined to 2.9-A resolutionCrystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA bindingDirected evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosisStructure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer TargetSmall Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based DesignDual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.Interrogating HIV integrase for compounds that bind- a SAMPL challengeThree new structures of the core domain of HIV-1 integrase: an active site that binds magnesiumHuman immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism.Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small moleculesBiochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.Soluble expression, purification and characterization of the full length IS2 Transposase.Application of protein engineering to enhance crystallizability and improve crystal properties.Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactorArchitecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linkingStructural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.Mapping viral DNA specificity to the central region of integrase by using functional human immunodeficiency virus type 1/visna virus chimeric proteinsRetroviral DNA integration.DNA shuffling as a tool for protein crystallizationCritical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.HIV integrase, a brief overview from chemistry to therapeutics.A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.Fragment-based screening by protein crystallography: successes and pitfalls.Prediction and analysis of protein solubility using a novel scoring card method with dipeptide compositionHIV-1 group O integrase displays lower enzymatic efficiency and higher susceptibility to raltegravir than HIV-1 group M subtype B integraseRetroviral Integrase Structure and DNA Recombination MechanismPrediction of solubility on recombinant expression of Plasmodium falciparum erythrocyte membrane protein 1 domains in Escherichia coli.Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity.Targeting HIV-1 integrase.Human immunodeficiency virus type 1 and related primate lentiviruses engage clathrin through Gag-Pol or Gag.Improvement of the crystallizability and expression of an RNA crystallization chaperoneModeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors.Fis, an accessorial factor for transcriptional activation of the mar (multiple antibiotic resistance) promoter of Escherichia coli in the presence of the activator MarA, SoxS, or Rob.Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA.Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivityStructure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activitySystematic replacement of lysine with glutamine and alanine in Escherichia coli malate synthase G: effect on crystallization.
P2860
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P2860
Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Catalytic domain of human immu ...... cement of hydrophobic residues
@ast
Catalytic domain of human immu ...... cement of hydrophobic residues
@en
Catalytic domain of human immu ...... cement of hydrophobic residues
@nl
type
label
Catalytic domain of human immu ...... cement of hydrophobic residues
@ast
Catalytic domain of human immu ...... cement of hydrophobic residues
@en
Catalytic domain of human immu ...... cement of hydrophobic residues
@nl
prefLabel
Catalytic domain of human immu ...... cement of hydrophobic residues
@ast
Catalytic domain of human immu ...... cement of hydrophobic residues
@en
Catalytic domain of human immu ...... cement of hydrophobic residues
@nl
P2093
P2860
P356
P1476
Catalytic domain of human immu ...... cement of hydrophobic residues
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.13.6057
P407
P577
1995-06-01T00:00:00Z