Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
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The generation and function of soluble apoE receptors in the CNSRationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solutionApolipoprotein J (clusterin) activates rodent microglia in vivo and in vitroCharacterizing affinity epitopes between prion protein and β-amyloid using an epitope mapping immunoassayProgressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsPathways towards and away from Alzheimer's diseaseAltered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature deathAmyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networksSoluble oligomers of the amyloid beta-protein impair synaptic plasticity and behaviorInsights into Mechanisms of Chronic NeurodegenerationTargeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeuticsTDP-43: a new player on the AD field?Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseasePrimate aging in the mammalian scheme: the puzzle of extreme variation in brain agingNLRP3 inflammasome: activation and regulation in age-related macular degenerationEffect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (review)Neuropathological alterations in Alzheimer diseaseStructural evolution and membrane interactions of Alzheimer's amyloid-beta peptide oligomers: new knowledge from single-molecule fluorescence studiesInteraction between prion protein and Aβ amyloid fibrils revisitedWireless-electrodeless quartz-crystal-microbalance biosensors for studying interactions among biomolecules: a review.Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.Intracellular cleavage of amyloid β by a viral protease NIa prevents amyloid β-mediated cytotoxicityInteractions between Aβ oligomers and presynaptic cholinergic signaling: age-dependent effects on attentional capacitiesCompounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeuticsReelin and apoE actions on signal transduction, synaptic function and memory formationProgesterone receptors: form and function in brainProtection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomersProtein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusInhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model fliesDirect observation of single amyloid-β(1-40) oligomers on live cells: binding and growth at physiological concentrationsClusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's diseaseNa, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's diseaseExtracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouseAlzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicityAmyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03β-sheet propensity controls the kinetic pathways and morphologies of seeded peptide aggregation.Effects of frustration, confinement, and surface interactions on the dimerization of an off-lattice beta-barrel protein.Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomersRole of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway
P2860
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P2860
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@ast
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@en
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@nl
type
label
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@ast
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@en
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@nl
prefLabel
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@ast
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@en
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@nl
P2093
P1476
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
@en
P2093
P304
P356
10.1016/S0166-2236(00)01749-5
P577
2001-04-01T00:00:00Z