Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding. - Wikidata - wikimedia - TriplyDB

Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding.

Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding.

http://www.wikidata.org/entity/Q34186694

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Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT Mechanisms of dopamine transporter regulation in normal and disease states X-ray structure of dopamine transporter elucidates antidepressant mechanism Designing modulators of monoamine transporters using virtual screening techniques Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter Neurotransmitter and psychostimulant recognition by the dopamine transporter.The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics Thermal Stability of Dopamine Transporters.2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations.SLC6 transporters: structure, function, regulation, disease association and therapeutics Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease.Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113.Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter.Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid.Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin Amphetamines, new psychoactive drugs and the monoamine transporter cycle.Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation.Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation.Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope Importance of cholesterol in dopamine transporter function.Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding.A role for sigma receptors in stimulant self-administration and addiction.Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter.The dopamine transporter role in psychiatric phenotypes.HIV, Tat and dopamine transmission.Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer.Single-quantum-dot tracking reveals altered membrane dynamics of an attention-deficit/hyperactivity-disorder-derived dopamine transporter coding variant.Alternating access mechanisms of LeuT-fold transporters: trailblazing towards the promised energy landscapes.Palmitoylation mechanisms in dopamine transporter regulation.Recent advances in nanodisc technology for membrane protein studies (2012-2017).Regulation of the Ca(2+)-ATPase by cholesterol: a specific or non-specific effect?Radioligand binding to nanodisc-reconstituted membrane transporters assessed by the scintillation proximity assay Dopamine transporter is enriched in filopodia and induces filopodia formation.

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P2860

Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding.

http://www.wikidata.org/entity/Q34186694

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Membrane cholesterol modulates ...... er and alters cocaine binding.

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Membrane cholesterol modulates ...... er and alters cocaine binding.

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Membrane cholesterol modulates ...... er and alters cocaine binding.

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Membrane cholesterol modulates ...... er and alters cocaine binding.

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Membrane cholesterol modulates ...... er and alters cocaine binding.

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Membrane cholesterol modulates ...... er and alters cocaine binding.

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Membrane cholesterol modulates ...... er and alters cocaine binding.

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Membrane cholesterol modulates ...... er and alters cocaine binding.

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Journal of Biological Chemistry

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Weimin C Hong

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P2860

Plasma membrane monoamine transporters: structure, regulation and function

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

A competitive inhibitor traps LeuT in an open-to-out conformation.

Functional rafts in cell membranes

The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands

SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis

Partitioning of the serotonin transporter into lipid microdomains modulates transport of serotonin

Regulated internalization and phosphorylation of the native norepinephrine transporter in response to phorbol esters. Evidence for localization in lipid rafts and lipid raft-mediated internalization

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

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