Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. - Wikidata - wikimedia - TriplyDB

Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.

Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.

http://www.wikidata.org/entity/Q35429841

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Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers Potential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and Methamphetamine Stimulants as specific inducers of dopamine-independent σ agonist self-administration in rats σ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration Opioid activation of toll-like receptor 4 contributes to drug reinforcement Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters.2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations.SLC6 transporters: structure, function, regulation, disease association and therapeutics Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease.Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration.DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.Novel C-1 substituted cocaine analogs unlike cocaine or benztropine.Self-administration of cocaine induces dopamine-independent self-administration of sigma agonists.A role for sigma receptors in stimulant self-administration and addiction.Identification of the Sigma-2 Receptor: Distinct from the Progesterone Receptor Membrane Component 1 (PGRMC1).Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies.Trace Amine-Associated Receptor Type 1 as A Target for The Development of Treatments for Stimulant Abuse.Cocaine Antagonists; Studies on Cocaine Self-Administration.Role of the σRs for Development of Medications Medications Discovery: Importance of Assessment of Drug Self Administration Dose-Effect Curves.Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change.Identification of Antagonists Selective for Sigma Receptor Subtypes that are Active In vivo.DAT Conformation Does Not Predict the Ability of Atypical Dopamine Uptake Inhibitors to Substitute for Cocaine.Lack of Effects of Toll-Like Receptor 4 Antagonists on the Reinforcing Effects of Cocaine and Remifentanil.2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter.Sigma Receptors and Substance Use Disorders.Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.Behavioral economic analysis of the effects of N-substituted benztropine analogs on cocaine self-administration in rats.The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic.Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.A Role for Sigma Receptors in Stimulant Self-Administration and Addiction.

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Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.

http://www.wikidata.org/entity/Q35429841

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Decreases in cocaine self-admi ...... e transporter and σ receptors.

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Decreases in cocaine self-admi ...... e transporter and σ receptors.

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type

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Decreases in cocaine self-admi ...... e transporter and σ receptors.

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Decreases in cocaine self-admi ...... e transporter and σ receptors.

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Decreases in cocaine self-admi ...... e transporter and σ receptors.

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Decreases in cocaine self-admi ...... e transporter and σ receptors.

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JPET.111.185025

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Journal of Pharmacology and Experimental Therapeutics

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Decreases in cocaine self-admi ...... e transporter and σ receptors.

@en

P2093

Gianluigi Tanda

http://www.w3.org/2001/XMLSchema#string

Jianjing Cao

http://www.w3.org/2001/XMLSchema#string

Jonathan L Katz

http://www.w3.org/2001/XMLSchema#string

Paul L Soto

http://www.w3.org/2001/XMLSchema#string

Stephen J Kohut

http://www.w3.org/2001/XMLSchema#string

Takato Hiranita

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Theresa Kopajtic

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P2860

Targeting sigma receptors: novel medication development for drug abuse and addiction

Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine

Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice

Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle.

Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding.

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine

Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes.

Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats.

Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.

Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.

P304

662-677

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scholarly article

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10.1124/JPET.111.185025

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2

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339

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Amy Hauck Newman

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2011-08-22T00:00:00Z

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51588678

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21859929

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3199989

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