Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissue.
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5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2).Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairsMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesEpigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcomeLysine residues direct the chlorination of tyrosines in YXXK motifs of apolipoprotein A-I when hypochlorous acid oxidizes high density lipoprotein.Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation.Specific sequence motifs direct the oxygenation and chlorination of tryptophan by myeloperoxidase.Characterization of synthetic oligonucleotides containing biologically important modified bases by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Comparative study of HOCl-inflicted damage to bacterial DNA ex vivo and within cellsExcision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.Chemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation.Polymerase incorporation and miscoding properties of 5-chlorouracil.Determination of hypersensitivity to genotoxic agents among Escherichia coli single gene knockout mutantsMyeloperoxidase-derived oxidation: mechanisms of biological damage and its preventionMutagenic consequences of cytosine alterations site-specifically embedded in the human genome.Epigenetics of chronic rhinosinusitis and the role of the eosinophil.Influence of environmental exposure on human epigenetic regulationMeasuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?Chemistry meets biology in colitis-associated carcinogenesisEpigenomics in environmental health.Base pairing configuration and stability of an oligonucleotide duplex containing a 5-chlorouracil-adenine base pair.pH-Dependent configurations of a 5-chlorouracil-guanine base pair.Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty.Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability.Mechanisms of base selection by the Escherichia coli mispaired uracil glycosylase.Expressions of some vital molecules: glioblastoma multiforme versus normal tissues.Tautomerism of the natural thymidine nucleoside and the antiviral analogue D4T. Structure and influence of an aqueous environment using MP2 and DFT methods.Endogenous formation of novel halogenated 2'-deoxycytidine. Hypohalous acid-mediated DNA modification at the site of inflammation.Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase.NADPH oxidase restrains the matrix metalloproteinase activity of macrophages.Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages.Halogen bonding versus hydrogen bonding induced 2D self-assembled nanostructures at the liquid-solid interface revealed by STM.The presence of modified nucleosides in extracellular fluids leads to the specific incorporation of 5-chlorocytidine into RNA and modulates the transcription and translation.The 5-chlorouracil:7-deazaadenine base pair as an alternative to the dT:dA base pair
P2860
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P2860
Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissue.
description
2003 nî lūn-bûn
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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2003 թվականի ապրիլին հրատարակված գիտական հոդված
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年學術文章
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name
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@ast
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@en
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@nl
type
label
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@ast
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@en
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@nl
prefLabel
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@ast
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@en
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@nl
P2093
P2860
P356
P1476
Phagocytes produce 5-chloroura ...... in human inflammatory tissue.
@en
P2093
Jaeman Byun
Jay W Heinecke
Jeffrey P Henderson
Junko Takeshita
P2860
P304
23522-23528
P356
10.1074/JBC.M303928200
P407
P577
2003-04-21T00:00:00Z