Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.
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Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNALesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNAThymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sitesCrystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognitionBiochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNACrystal Structure of Human Methyl-Binding Domain IV Glycosylase Bound to Abasic DNAStructural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residuesRole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesA germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformationDependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairsThymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNABase excision repair of tandem modifications in a methylated CpG dinucleotide.Polymerase incorporation and miscoding properties of 5-chlorouracil.E2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex.Recent advances in the structural mechanisms of DNA glycosylasesA mammalian-like DNA damage response of fission yeast to nucleoside analogsImpact of base analogues within a CpG dinucleotide on the binding of DNA by the methyl-binding domain of MeCP2 and methylation by DNMT1Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNAEffect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging.Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase.Rapid deamination of cyclobutane pyrimidine dimer photoproducts at TCG sites in a translationally and rotationally positioned nucleosome in vivo.7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.Weakened N3 Hydrogen Bonding by 5-Formylcytosine and 5-Carboxylcytosine Reduces Their Base-Pairing StabilityCharacterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in VivoMechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylaseROS1 5-methylcytosine DNA glycosylase is a slow-turnover catalyst that initiates DNA demethylation in a distributive fashion.Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase.Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA.Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.pH-Dependent configurations of a 5-chlorouracil-guanine base pair.Recognition of damaged DNA: structure and dynamic markers.Quantification of Oxidized 5-Methylcytosine Bases and TET Enzyme Activity.The antileukaemic cell cycle regulatory activities of swainsonine purified from Metarhizium anisopliae fermentation broth.NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1.Developing an in silico model of the modulation of base excision repair using methoxyamine for more targeted cancer therapeutics.Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex.Solid-State Nanopore Analysis of Diverse DNA Base Modifications Using a Modular Enzymatic Labeling Process.The correlation of genome size and DNA methylation rate in metazoans.
P2860
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P2860
Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Excision of 5-halogenated urac ...... r DNA contexts other than CpG.
@ast
Excision of 5-halogenated urac ...... r DNA contexts other than CpG.
@en
type
label
Excision of 5-halogenated urac ...... r DNA contexts other than CpG.
@ast
Excision of 5-halogenated urac ...... r DNA contexts other than CpG.
@en
prefLabel
Excision of 5-halogenated urac ...... r DNA contexts other than CpG.
@ast
Excision of 5-halogenated urac ...... r DNA contexts other than CpG.
@en
P2860
P356
P1476
Excision of 5-halogenated urac ...... or DNA contexts other than CpG
@en
P2093
Matthew T Bennett
Michael T Morgan
P2860
P304
27578-27586
P356
10.1074/JBC.M704253200
P407
P577
2007-06-29T00:00:00Z