Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
about
Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsA Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulationSecond nature: biological functions of the Raf-1 "kinase"Raf family kinases: old dogs have learned new tricksSpatial regulation of Raf kinase signaling by RKTGCommon variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activationProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesEtiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosisRaf-interactome in tuning the complexity and diversity of Raf function.Negative feedback regulation of the ERK1/2 MAPK pathwayRaf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activationTemporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiationRegulation of sprouty stability by Mnk1-dependent phosphorylation.The VASP-Spred-Sprouty domain puzzle.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.Spred1, a negative regulator of Ras-MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure.Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loopSprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoidsGenome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseasesThe developing story of Sprouty and cancer.Functional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2.Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGFOverexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.SPRY1 promotes the degradation of uPAR and inhibits uPAR-mediated cell adhesion and proliferationTesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing FieldIdentification of a new Sprouty protein responsible for the inhibition of the Bombyx mori nucleopolyhedrovirus reproductionRegulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteinsSprouty-2 regulates oncogenic K-ras in lung development and tumorigenesisConcomitant BET and MAPK blockade for effective treatment of ovarian cancer.Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract.Epigenetic: a molecular link between testicular cancer and environmental exposures.SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor.Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responsesRaf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells.
P2860
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P2860
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@ast
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@en
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@nl
type
label
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@ast
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@en
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@nl
prefLabel
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@ast
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@en
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@nl
P2093
P356
P1433
P1476
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
@en
P2093
Akihiko Yoshimura
Atsuo Sasaki
Atsushi Nonami
Kazuko Saeki
Masabumi Shibuya
Masamitsu Kuriyama
Mika Sasaki
Naoaki Saito
Reiko Kato
Takaharu Taketomi
P2888
P304
P356
10.1038/NCB978
P577
2003-05-01T00:00:00Z
P5875
P6179
1000025587