Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. - Wikidata - wikimedia - TriplyDB

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

http://www.wikidata.org/entity/Q34193175

about

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation Second nature: biological functions of the Raf-1 "kinase"Raf family kinases: old dogs have learned new tricks Spatial regulation of Raf kinase signaling by RKTG Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis Raf-interactome in tuning the complexity and diversity of Raf function.Negative feedback regulation of the ERK1/2 MAPK pathway Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation Regulation of sprouty stability by Mnk1-dependent phosphorylation.The VASP-Spred-Sprouty domain puzzle.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.Spred1, a negative regulator of Ras-MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure.Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoids Genome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseases The developing story of Sprouty and cancer.Functional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2.Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.SPRY1 promotes the degradation of uPAR and inhibits uPAR-mediated cell adhesion and proliferation Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field Identification of a new Sprouty protein responsible for the inhibition of the Bombyx mori nucleopolyhedrovirus reproduction Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis Concomitant BET and MAPK blockade for effective treatment of ovarian cancer.Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract.Epigenetic: a molecular link between testicular cancer and environmental exposures.SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor.Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells.

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Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

http://www.wikidata.org/entity/Q34193175

description

2003 nî lūn-bûn

@nan

2003 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի մայիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

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2003年论文

@wuu

name

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@ast

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@en

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@nl

type

label

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@ast

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@en

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@nl

prefLabel

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@ast

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@en

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@nl

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Nature Cell Biology

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Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

@en

P2093

Akihiko Yoshimura

http://www.w3.org/2001/XMLSchema#string

Atsuo Sasaki

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Atsushi Nonami

http://www.w3.org/2001/XMLSchema#string

Kazuko Saeki

http://www.w3.org/2001/XMLSchema#string

Masabumi Shibuya

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Masamitsu Kuriyama

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Mika Sasaki

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Naoaki Saito

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Reiko Kato

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Takaharu Taketomi

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427-432

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scholarly article

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10.1038/NCB978

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5

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5

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2003-05-01T00:00:00Z

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10786018

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1000025587

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12717443

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