An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele
about
Modeling the study of DNA damage responses in miceTransgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaksDifferential regulation of components of the ubiquitin-proteasome pathway during lens cell differentiationInsights into cancer from transgenic mouse models.Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis."Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normallySuppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cellsIncreased p53 activity does not accelerate telomere-driven ageing.Lens fibre cell differentiation and organelle loss: many paths lead to clarity.The cellular and molecular mechanisms of vertebrate lens development.Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens developmentp53 E3 ubiquitin protein ligase homolog regulates p53 in vivo in the adult mouse eye lensNucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization.The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents.Apoptosis, neurotrophic factors and neurodegeneration.HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress.Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans.
P2860
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P2860
An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
An apoptotic defect in lens di ...... is rescued by a mutant allele
@ast
An apoptotic defect in lens di ...... is rescued by a mutant allele
@en
An apoptotic defect in lens di ...... is rescued by a mutant allele
@nl
type
label
An apoptotic defect in lens di ...... is rescued by a mutant allele
@ast
An apoptotic defect in lens di ...... is rescued by a mutant allele
@en
An apoptotic defect in lens di ...... is rescued by a mutant allele
@nl
prefLabel
An apoptotic defect in lens di ...... is rescued by a mutant allele
@ast
An apoptotic defect in lens di ...... is rescued by a mutant allele
@en
An apoptotic defect in lens di ...... is rescued by a mutant allele
@nl
P2093
P2860
P356
P1476
An apoptotic defect in lens di ...... is rescued by a mutant allele
@en
P2093
Nakamura T
Westphal H
Williams-Simons L
P2860
P304
P356
10.1073/PNAS.92.13.6142
P407
P577
1995-06-01T00:00:00Z