about
Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cellsZinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cellsHighly specific zinc finger proteins obtained by directed domain shuffling and cell-based selectionNeuroprotective therapies in glaucoma: II. Genetic nanotechnology toolsZinc and the prooxidant heart failure phenotypeThe prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disordersThe prokaryotic zinc-finger: structure, function and comparison with the eukaryotic counterpartHighly efficient endogenous human gene correction using designed zinc-finger nucleasesGene targeting using zinc finger nucleasesThe minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding proteinTranscription factors in long-term memory and synaptic plasticityUtrophin up-regulation by an artificial transcription factor in transgenic miceA classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoysEstablishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleasesBinding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-κB Essential Modulator).Zinc-finger-based transcriptional repression of rhodopsin in a model of dominant retinitis pigmentosa.RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription.A phage display selection of engrailed homeodomain mutants and the importance of residue Q50.Nutrient-gene interactions: a single nutrient and hundreds of target genes.Laboratory-directed protein evolutionProfiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based methodTailor-made zinc-finger transcription factors activate FLO11 gene expression with phenotypic consequences in the yeast Saccharomyces cerevisiae.Phenotypic engineering by reprogramming gene transcription using novel artificial transcription factors in Escherichia coliRapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).Zinc finger nucleases as tools to understand and treat human diseases.Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.Targeted gene suppression by inducing de novo DNA methylation in the gene promoter.Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.Genomic repertoires of DNA-binding transcription factors across the tree of life.Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line.Efficient gene targeting in Drosophila with zinc-finger nucleasesMetallothioneins and zinc in cancer diagnosis and therapy.Targeting artificial transcription factors to the utrophin A promoter: effects on dystrophic pathology and muscle function.Strand invasion of mixed-sequence, double-helical B-DNA by γ-peptide nucleic acids containing G-clamp nucleobases under physiological conditions.Targeted genome engineering via zinc finger nucleasesEpigenetic approaches to psychiatric disorders.Current advances in retroviral gene therapy.Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Drug discovery with engineered zinc-finger proteins.
@ast
Drug discovery with engineered zinc-finger proteins.
@en
Drug discovery with engineered zinc-finger proteins.
@nl
type
label
Drug discovery with engineered zinc-finger proteins.
@ast
Drug discovery with engineered zinc-finger proteins.
@en
Drug discovery with engineered zinc-finger proteins.
@nl
prefLabel
Drug discovery with engineered zinc-finger proteins.
@ast
Drug discovery with engineered zinc-finger proteins.
@en
Drug discovery with engineered zinc-finger proteins.
@nl
P2093
P356
P1476
Drug discovery with engineered zinc-finger proteins.
@en
P2093
Andrew C Jamieson
Carl O Pabo
Jeffrey C Miller
P2888
P304
P356
10.1038/NRD1087
P577
2003-05-01T00:00:00Z
P6179
1040287926