Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX. - Wikidata - wikimedia - TriplyDB

Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.

Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.

http://www.wikidata.org/entity/Q34197559

about

The gene therapy journey for hemophilia: are we there yet?Animal models of hemophilia Gene therapy in an era of emerging treatment options for hemophilia B IL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophilia Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis.Nuclear factor (NF)-κB and its associated pathways are major molecular regulators of blood-induced joint damage in a murine model of hemophilia.Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency.Employing a gain-of-function factor IX variant R338L to advance the efficacy and safety of hemophilia B human gene therapy: preclinical evaluation supporting an ongoing adeno-associated virus clinical trial.Joint bleeding in factor VIII deficient mice causes an acute loss of trabecular bone and calcification of joint soft tissues which is prevented with aggressive factor replacement.Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC.Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue Treatment of Hemophilia A in Utero and Postnatally using Sheep as a Model for Cell and Gene Delivery Arthritis gene therapy and its tortuous path into the clinic.Wound healing in hemophilia B mice and low tissue factor mice.Unique strategies for therapeutic gene transfer in haemophilia A and haemophilia BWFH State-of-the-Art Session on Therapeutic Gene Transfer Buenos Aires, Argentina.Getting arthritis gene therapy into the clinic.Pathophysiology, diagnosis and prevention of arthropathy in patients with haemophilia.Will gene therapy trump factor treatment in hemophilia?New approaches to gene and cell therapy for hemophilia.New and improved AAVenues: current status of hemophilia B gene therapy.Application of polyploid adeno-associated virus vectors for transduction enhancement and neutralizing antibody evasion.Recent tissue engineering-based advances for effective rAAV-mediated gene transfer in the musculoskeletal system.Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis.Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia.MicroRNA-15b Modulates Molecular Mediators of Blood Induced Arthropathy in Hemophilia Mice.Gene Delivery of Activated Factor VII Using Alternative Adeno-Associated Virus Serotype Improves Hemostasis in Hemophiliac Mice with FVIII Inhibitors and Adeno-Associated Virus Neutralizing Antibodies.Orthopedic gene therapy--lost in translation?Alternative strategies for gene therapy of hemophilia.Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis.The expanding menagerie: animal models of hemophilia A.A fusion protein of interleukin-4 and interleukin-10 protects against blood-induced cartilage damage in vitro and in vivo.Experimental study on the role of intra-articular injection of MSCs on cartilage regeneration in haemophilia.Models for assessing immunogenicity and efficacy of new therapeutics for the treatment of haemophilia.The clotting system - a major player in wound healing.Optimizing joint function: new knowledge and novel tools and treatments.Intra-articular injection of mesenchymal stem cells expressing coagulation factor ameliorates hemophilic arthropathy in factor VIII-deficient mice.

P2860

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P2860

Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.

http://www.wikidata.org/entity/Q34197559

description

2008 nî lūn-bûn

@nan

2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի օգոստոսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Intraarticular factor IX prote ...... ence of circulating factor IX.

@ast

Intraarticular factor IX prote ...... ence of circulating factor IX.

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Intraarticular factor IX prote ...... ence of circulating factor IX.

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type

label

Intraarticular factor IX prote ...... ence of circulating factor IX.

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Intraarticular factor IX prote ...... ence of circulating factor IX.

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Intraarticular factor IX prote ...... ence of circulating factor IX.

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prefLabel

Intraarticular factor IX prote ...... ence of circulating factor IX.

@ast

Intraarticular factor IX prote ...... ence of circulating factor IX.

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Intraarticular factor IX prote ...... ence of circulating factor IX.

@nl

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P356

BLOOD-2008-01-131417

P1433

P1476

Intraarticular factor IX prote ...... ence of circulating factor IX.

@en

P2093

Brian L Feldman

http://www.w3.org/2001/XMLSchema#string

Junjiang Sun

http://www.w3.org/2001/XMLSchema#string

Leonard A Valentino

http://www.w3.org/2001/XMLSchema#string

Narine Hakobyan

http://www.w3.org/2001/XMLSchema#string

Paul E Monahan

http://www.w3.org/2001/XMLSchema#string

R Jude Samulski

http://www.w3.org/2001/XMLSchema#string

P2860

Creation of a mouse expressing defective human factor IX

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Arthrocentesis of the knee in acute hemophilic arthropathy.

Optical imaging of luminescence for in vivo quantification of gene electrotransfer in mouse muscle and knee.

Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia.

Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection.

Effect of thrombin inhibition on synovial inflammation in antigen induced arthritis

Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector.

Hemophilic arthropathy.

The target joint.

P304

4532-4541

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P31

scholarly article

P356

10.1182/BLOOD-2008-01-131417

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P407

P433

12

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P478

112

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P577

2008-08-20T00:00:00Z

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P5875

23183339

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P698

18716130

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P921

Coagulation factor IX

P932

2954682

http://www.w3.org/2001/XMLSchema#string