Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.
about
The gene therapy journey for hemophilia: are we there yet?Animal models of hemophiliaGene therapy in an era of emerging treatment options for hemophilia BIL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophiliaOptimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis.Nuclear factor (NF)-κB and its associated pathways are major molecular regulators of blood-induced joint damage in a murine model of hemophilia.Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency.Employing a gain-of-function factor IX variant R338L to advance the efficacy and safety of hemophilia B human gene therapy: preclinical evaluation supporting an ongoing adeno-associated virus clinical trial.Joint bleeding in factor VIII deficient mice causes an acute loss of trabecular bone and calcification of joint soft tissues which is prevented with aggressive factor replacement.Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC.Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissueTreatment of Hemophilia A in Utero and Postnatally using Sheep as a Model for Cell and Gene DeliveryArthritis gene therapy and its tortuous path into the clinic.Wound healing in hemophilia B mice and low tissue factor mice.Unique strategies for therapeutic gene transfer in haemophilia A and haemophilia BWFH State-of-the-Art Session on Therapeutic Gene Transfer Buenos Aires, Argentina.Getting arthritis gene therapy into the clinic.Pathophysiology, diagnosis and prevention of arthropathy in patients with haemophilia.Will gene therapy trump factor treatment in hemophilia?New approaches to gene and cell therapy for hemophilia.New and improved AAVenues: current status of hemophilia B gene therapy.Application of polyploid adeno-associated virus vectors for transduction enhancement and neutralizing antibody evasion.Recent tissue engineering-based advances for effective rAAV-mediated gene transfer in the musculoskeletal system.Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis.Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia.MicroRNA-15b Modulates Molecular Mediators of Blood Induced Arthropathy in Hemophilia Mice.Gene Delivery of Activated Factor VII Using Alternative Adeno-Associated Virus Serotype Improves Hemostasis in Hemophiliac Mice with FVIII Inhibitors and Adeno-Associated Virus Neutralizing Antibodies.Orthopedic gene therapy--lost in translation?Alternative strategies for gene therapy of hemophilia.Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis.The expanding menagerie: animal models of hemophilia A.A fusion protein of interleukin-4 and interleukin-10 protects against blood-induced cartilage damage in vitro and in vivo.Experimental study on the role of intra-articular injection of MSCs on cartilage regeneration in haemophilia.Models for assessing immunogenicity and efficacy of new therapeutics for the treatment of haemophilia.The clotting system - a major player in wound healing.Optimizing joint function: new knowledge and novel tools and treatments.Intra-articular injection of mesenchymal stem cells expressing coagulation factor ameliorates hemophilic arthropathy in factor VIII-deficient mice.
P2860
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P2860
Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Intraarticular factor IX prote ...... ence of circulating factor IX.
@ast
Intraarticular factor IX prote ...... ence of circulating factor IX.
@en
Intraarticular factor IX prote ...... ence of circulating factor IX.
@nl
type
label
Intraarticular factor IX prote ...... ence of circulating factor IX.
@ast
Intraarticular factor IX prote ...... ence of circulating factor IX.
@en
Intraarticular factor IX prote ...... ence of circulating factor IX.
@nl
prefLabel
Intraarticular factor IX prote ...... ence of circulating factor IX.
@ast
Intraarticular factor IX prote ...... ence of circulating factor IX.
@en
Intraarticular factor IX prote ...... ence of circulating factor IX.
@nl
P2093
P2860
P1433
P1476
Intraarticular factor IX prote ...... ence of circulating factor IX.
@en
P2093
Brian L Feldman
Junjiang Sun
Leonard A Valentino
Narine Hakobyan
Paul E Monahan
R Jude Samulski
P2860
P304
P356
10.1182/BLOOD-2008-01-131417
P407
P577
2008-08-20T00:00:00Z